Literature DB >> 1249204

Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent nonsuppressible component of secretion.

G P Mayer, J F Habener, J T Potts.   

Abstract

The response of normal bovine parathyroid glands to hypercalcemia was assessed in vivo by radioimmunoassay of immunoreactive parathyroid hormone concentrations in parathyroid effluent blood obtained by surgical cannulation of both anesthetized and nonanesthetized calves. Hypercalcemia was induced for periods of 0.3-35 h by intravenous infusion of a solution of calcium chloride. Assessment of immunoreactivity in effluent and peripheral blood included measurements of selected samples by use of a radioimmunoassay specific for a site residing in the biologically active portion of the hormone molecule. In all instances, the concentration of immunoreactive parathyroid hormone in hypercalcemic venous effluent from a superior parathyroid gland exceeded that of the peripheral blood. Failure of hypercalcemia to suppress completely secretion by normal parathyroids indicates that a portion of parathyroid hormone secretion occurs independent of blood calcium concentration. Consequently, continued parathyroid hormone secretion despite hypercalcemia can no longer be regarded as a unique feature of parathyroid neoplasia.

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Year:  1976        PMID： 1249204      PMCID： PMC436701          DOI： 10.1172/JCI108324

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  14 in total

1.  IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE.

Authors:  S A Berson; R S Yalow; G D Aurbach; J T Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1963-05       Impact factor: 11.205

2.  Non-autonomy of hormone secretion in primary hyperparathyroidism.

Authors:  T M Murray; M Peacock; D Powell; J M Monchik; J T Potts
Journal:  Clin Endocrinol (Oxf)       Date:  1972-07       Impact factor: 3.478

3.  Parathyroid hormone responses during spontaneous hypocalcemia and induced hypercalcemia in cows.

Authors:  J W Blum; G P Mayer; J T Potts
Journal:  Endocrinology       Date:  1974-07       Impact factor: 4.736

4.  Isolation and characterization of the bovine parathyroid isohormones.

Authors:  H T Keutmann; G D Aurbach; B F Dawson; H D Niall; L J Deftos; J T Potts
Journal:  Biochemistry       Date:  1971-07-06       Impact factor: 3.162

5.  Regulation of parathyroid hormone secretion in vitro: quantitative aspects of calcium and magnesium ion control.

Authors:  J H Targovnik; J S Rodman; L M Sherwood
Journal:  Endocrinology       Date:  1971-06       Impact factor: 4.736

6.  Experimental hyperparathyroidism from multiple isologous parathyroid transplants: homeostatic effect of simultaneous thyroid transplants.

Authors:  R F Gittes; I C Radde
Journal:  Endocrinology       Date:  1966-05       Impact factor: 4.736

7.  Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS.

Authors:  G V Segre; J F Habener; D Powell; G W Tregear; J T Potts
Journal:  J Clin Invest       Date:  1972-12       Impact factor: 14.808

8.  Activation of renal cortical adenylate cyclase by circulating immunoreactive parathyroid hormone fragments.

Authors:  J M Canterbury; G S Levey; E Reiss
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808

9.  Heterogeneity of parathyroid hormone. Clinical and physiologic implications.

Authors:  R Silverman; R S Yalow
Journal:  J Clin Invest       Date:  1973-08       Impact factor: 14.808

10.  Parathyroid hormone: secretion and metabolism in vivo.

Authors:  J F Habener; D Powell; T M Murray; G P Mayer; J T Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205
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  13 in total

Review 1.  Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

Authors:  H W Seyberth
Journal:  Klin Wochenschr       Date:  1978-04-15

2.  Heterogeneous response to calcium by individual parathyroid cells.

Authors:  F Sun; C K Ritchie; C Hassager; P Maercklein; L A Fitzpatrick
Journal:  J Clin Invest       Date:  1993-02       Impact factor: 14.808

3.  In vitro perifusion for the study of parathyroid hormone secretion: effects of extracellular calcium concentration and beta-adrenergic regulation on bovine parathyroid hormone secretion in vitro.

Authors:  D A Hanley; K Takatsuki; M E Birnbaumer; A B Schneider; L M Sherwood
Journal:  Calcif Tissue Int       Date:  1980       Impact factor: 4.333

Review 4.  Hormonal derangements in uremia.

Authors:  G Tolis; D Goltzman; H Guyda; T Mountokalakis
Journal:  J Endocrinol Invest       Date:  1980 Jan-Mar       Impact factor: 4.256

5.  Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro.

Authors:  D A Hanley; K Takatsuki; J M Sultan; A B Schneider; L M Sherwood
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

6.  Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro.

Authors:  J F Habener
Journal:  J Clin Invest       Date:  1978-08       Impact factor: 14.808

7.  Correlation of electron microscopic and secretory response of human parathyroid adenomas with different calcium concentrations in organ culture.

Authors:  M Dietel; E Altenähr; R Montz; J Hagemann; G Dorn
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1978-06-15

8.  Primary hyperparathyroidism: four- to eight-year postoperative follow-up demonstrating persistent functional insignificance of microscopic parathyroid hyperplasia and decreased autonomy of parathyroid hormone release.

Authors:  T S Harrison; B Duarte; R E Reitz; R Princenthal; J F Seaton; E M Badder; W P Graham
Journal:  Ann Surg       Date:  1981-10       Impact factor: 12.969

9.  The release of parathyroid hormone and the exocytosis of a proteoglycan are modulated by extracellular Ca2+ in a similar manner.

Authors:  Z Muresan; R R MacGregor
Journal:  Mol Biol Cell       Date:  1994-07       Impact factor: 4.138

10.  [Hyperparathyroidism in hemodialysis patients: studies on parathyroid regulation and classification problems (author's transl)].

Authors:  R Augustin; W H Hackeng
Journal:  Klin Wochenschr       Date:  1981-11-16
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