Literature DB >> 12487327

Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract.

G Arunachalam1, D Chattopadhyay, S Chatterjee, A B Mandal, T K Sur, S C Mandal.   

Abstract

Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o. and its fractions at 25 mg kg(-1) and 50 mg kg(-1), p.o. showed the significant dose dependent antiinflammatory activity in carrageenan and dextran-induced rats hind paw edema (acute models) as well as in cotton pellet-induced granuloma (chronic model) in rats. Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg kg(-1)).

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Year:  2002        PMID： 12487327     DOI： 10.1078/094471102321616445

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  5 in total

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  5 in total

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