Literature DB >> 12482782

Therapeutic inhibition of tumour necrosis factor alpha in patients with heart failure: cooling an inflamed heart.

P A Henriksen1, D E Newby.   

Abstract

Heart failure is a systemic disorder characterised by tissue hypoxia and secondary organ dysfunction which occurs in response to various myocardial insults that include ischaemia, viral infections, and toxins. In addition to maladaptive neurohumoral activation, heart failure is associated with an inflammatory state that appears to have a detrimental effect on cardiac function and prognosis. This has led to the suggestion that anti-inflammatory interventions may have therapeutic potential in the symptomatic and prognostic treatment of patients with heart failure. This review considers the role of inhibition of the cytokine tumour necrosis factor alpha in the treatment of heart failure.

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Year:  2003        PMID： 12482782      PMCID： PMC1767517          DOI： 10.1136/heart.89.1.14

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  47 in total

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Authors:  B Levine; J Kalman; L Mayer; H M Fillit; M Packer
Journal:  N Engl J Med       Date:  1990-07-26       Impact factor: 91.245

2.  Beneficial effects of pentoxifylline in patients with idiopathic dilated cardiomyopathy treated with angiotensin-converting enzyme inhibitors and carvedilol: results of a randomized study.

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Journal:  Circulation       Date:  2001-02-27       Impact factor: 29.690

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Journal:  Science       Date:  1992-07-17       Impact factor: 47.728

4.  Activation of coagulation after administration of tumor necrosis factor to normal subjects.

Authors:  T van der Poll; H R Büller; H ten Cate; C H Wortel; K A Bauer; S J van Deventer; C E Hack; H P Sauerwein; R D Rosenberg; J W ten Cate
Journal:  N Engl J Med       Date:  1990-06-07       Impact factor: 91.245

5.  Evidence of oxidative stress in chronic heart failure in humans.

Authors:  J McMurray; M Chopra; I Abdullah; W E Smith; H J Dargie
Journal:  Eur Heart J       Date:  1993-11       Impact factor: 29.983

6.  Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Authors:  K K Griendling; C A Minieri; J D Ollerenshaw; R W Alexander
Journal:  Circ Res       Date:  1994-06       Impact factor: 17.367

7.  The cardiovascular response of normal humans to the administration of endotoxin.

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Journal:  N Engl J Med       Date:  1989-08-03       Impact factor: 91.245

8.  Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

Authors:  T Yokoyama; L Vaca; R D Rossen; W Durante; P Hazarika; D L Mann
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

9.  Nitric oxide synthase activities in human myocardium.

Authors:  A J de Belder; M W Radomski; H J Why; P J Richardson; C A Bucknall; E Salas; J F Martin; S Moncada
Journal:  Lancet       Date:  1993-01-09       Impact factor: 79.321

10.  Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

Authors:  J McMurray; I Abdullah; H J Dargie; D Shapiro
Journal:  Br Heart J       Date:  1991-11
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  6 in total

1.  Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade.

Authors:  Z Yuan; Y Liu; Y Liu; J Zhang; C Kishimoto; Y Wang; A Ma; Z Liu
Journal:  Heart       Date:  2005-03-17       Impact factor: 5.994

Review 2.  Proinflammatory cytokines in heart failure: double-edged swords.

Authors:  Mona Hedayat; Mohammad Jafar Mahmoudi; Noel R Rose; Nima Rezaei
Journal:  Heart Fail Rev       Date:  2010-11       Impact factor: 4.214

3.  Effect of chronic hypoxic hypoxia on oxidation and glucuronidation of carvedilol in rats.

Authors:  Shizuka Yamaura; Miki Fukao; Kazuya Ishida; Masato Taguchi; Yukiya Hashimoto
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2013-06-06       Impact factor: 2.441

4.  The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression.

Authors:  Lihua Ao; Yong Song; David A Fullerton; Charles A Dinarello; Xianzhong Meng
Journal:  Cytokine       Date:  2007-08-01       Impact factor: 3.861

5.  Relaxin-3 Ameliorates Diabetic Cardiomyopathy by Inhibiting Endoplasmic Reticulum Stress.

Authors:  Li-Ya Pan; Xiao-Hui Zhang; Wu-Jie Xia; Jia-Lin Pan
Journal:  Comput Math Methods Med       Date:  2022-09-27       Impact factor: 2.809

Review 6.  Well-Known and Novel Serum Biomarkers for Risk Stratification of Patients with Non-ischemic Dilated Cardiomyopathy.

Authors:  Larisa Anghel; Radu Sascău; Ioana Mădălina Zota; Cristian Stătescu
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923
  6 in total

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