Literature DB >> 12482431

Dihydropyrimidinones--a new class of anti-staphylococcal antibiotics.

Michael Brands1, Rainer Endermann, Reinhold Gahlmann, Jochen Krüger, Siegfried Raddatz.   

Abstract

We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity and showed improved tolerability.

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Year:  2003        PMID: 12482431     DOI: 10.1016/s0960-894x(02)00880-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds.

Authors:  Vanitha Ramachandran; Karthiga Arumugasamy; Sanjeev Kumar Singh; Naushad Edayadulla; Penugonda Ramesh; Sathish-Kumar Kamaraj
Journal:  J Chem Biol       Date:  2015-07-04

2.  Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057.

Authors:  E Limburg; R Gahlmann; H-P Kroll; D Beyer
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

  2 in total

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