Literature DB >> 12480187

1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats.

Begoña Sanchez1, Elena Lopez-Martin, Carmen Segura, Jose L Labandeira-Garcia, Roman Perez-Fernandez.   

Abstract

Glial cell line-derived neurotrophic factor (GDNF) has been postulated as a possible candidate for therapeutic treatment in Parkinson's disease (PD). Recent in vitro data suggest that 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] treatment may enhance GDNF mRNA expression. In the present study, using semiquantitative RT-PCR and Western blot, we have shown that 1,25(OH)(2)D(3) administration intraperitoneally, significantly increases GDNF mRNA and protein levels in the striatum of adult rats.

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Year:  2002        PMID： 12480187     DOI： 10.1016/s0169-328x(02)00545-4

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  17 in total

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Review 5.  [Vitamin D and multiple sclerosis : the role for risk of disease and treatment].

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6.  Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone.

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7.  Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans.

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8.  1alpha,25-Dihydroxyvitamin D(3) Protects Dopaminergic Neurons in Rodent Models of Parkinson's Disease through Inhibition of Microglial Activation.

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Review 9.  Vitamin D as a potential therapy in amyotrophic lateral sclerosis.

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Review 10.  GDNF--a potential target to treat addiction.

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