Literature DB >> 12478783

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine.

Fanglu Huang1, Yanyan Li, Jinquan Yu, Jonathan B Spencer.   

Abstract

The gene btrR from Bacillus circulans has been cloned and expressed and shown to produce a protein which catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine.

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Year:  2002        PMID： 12478783     DOI： 10.1039/b209799k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Radical SAM enzymes in the biosynthesis of sugar-containing natural products.

Authors:  Mark W Ruszczycky; Yasushi Ogasawara; Hung-Wen Liu
Journal:  Biochim Biophys Acta       Date:  2011-12-07

2.  Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.

Authors:  Je Won Park; Jay Sung Joong Hong; Niranjan Parajuli; Won Seok Jung; Sung Ryeol Park; Si-Kyu Lim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-12       Impact factor: 11.205

3.  Exploration of Catalytic Selectivity for Aminotransferase (BtrR) Based on Multiple Molecular Dynamics Simulations.

Authors:  Ye Liu; Youzhong Wan; Jingxuan Zhu; Muxin Li; Zhengfei Yu; Jiarui Han; Zuoming Zhang; Weiwei Han
Journal:  Int J Mol Sci       Date:  2019-03-08       Impact factor: 5.923
  3 in total

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