Literature DB >> 12477937

An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa.

D Battogtokh1, D K Asch, M E Case, J Arnold, H-B Schuttler.   

Abstract

A chemical reaction network for the regulation of the quinic acid (qa) gene cluster of Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the parameter space of possible chemical reaction networks is developed to identify an ensemble of deterministic kinetics models with rate constants consistent with RNA and protein profiling data. This method was successful in identifying a model ensemble fitting available RNA profiling data on the qa gene cluster.

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Year:  2002        PMID： 12477937      PMCID： PMC139242          DOI： 10.1073/pnas.262658899

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

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Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

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10.  DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa.

Authors:  R F Geever; L Huiet; J A Baum; B M Tyler; V B Patel; B J Rutledge; M E Case; N H Giles
Journal:  J Mol Biol       Date:  1989-05-05       Impact factor: 5.469
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