Literature DB >> 12470744

Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.

James A Patch1, Annelise E Barron.   

Abstract

Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

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Year:  2002        PMID： 12470744     DOI： 10.1016/s1367-5931(02)00385-x

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  40 in total

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