| Literature DB >> 12463597 |
Jun-ichi Miyagi1, Naoki Kakazu, Masato Masuda, Takashi Miyagi, Tamiko Toyohama, Tetsuro Nakazato, Takeaki Tomoyose, Tetsuharu Shinjyo, Akitoshi Nagasaki, Naoya Taira, Misao Ohki, Tatsuo Abe, Nobuyuki Takasu.
Abstract
We report a case of acute myeloid leukemia (AML), M2 subtype according to the French-American-British (FAB) classification, with extramedullary myeloblastoma of the uterus and a masked type of variant translocation of t(8;21)(q22;q22). A 45-year-old Japanese woman presented with metrorrhagia, and AML (M2) with uterine invasion was diagnosed. The patient received an allogeneic peripheral blood stem cell transplantation after remission, and her pelvis was irradiated locally. Cytogenetic study at first showed t(8;17)(q22;p13) by G-banding. Spectral karyotyping (SKY) analysis modified this interpretation to a 3-way translocation involving chromosomes 8,17, and 21 and identified a masked type of variant t(8;21)(q22;q22) translocation. Results of fluorescence in situ hybridization using the AML1/ETO probe, and of detection of the AML1/ETO fusion transcript by reverse transcriptase-polymerase chain reaction were consistent with the karyotyping result. SKY analysis is useful to compensate for the limitations of cytogenetic studies.Entities:
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Year: 2002 PMID： 12463597 DOI： 10.1007/bf02982693
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490