Literature DB >> 1246055

Correlation analysis of Baker's studies on enzyme inhibition. 1. Guanine deaminase, xanthine oxidase, dihydrofolate reductase, and complement.

C Silipo, C Hansch.   

Abstract

Five correlation equations are presented which relate inhibitory activity of 578 inhibitors of guanine deaminase, xanthine oxidase, dihydrofolate reductase, and complement to their chemical structures. The use of correlation analysis in enzyme studies for drug development is discussed. The importance of indicator variables in such studies is emphasized.

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Year:  1976        PMID： 1246055     DOI： 10.1021/jm00223a014

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Evidence for the nonhydrophobic interaction of aromatic, nitrogen-containing compounds with the coenzyme binding site of a NAD-linked D-lactate dehydrogenase.

Authors:  G L Long; J R Cook; W R Ellington
Journal:  Experientia       Date:  1978-05-15

2.  Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.

Authors:  Saritha Tantravedi; Saibal Chakraborty; Niti H Shah; James C Fishbein; Ramachandra S Hosmane
Journal:  Bioorg Med Chem       Date:  2013-07-11       Impact factor: 3.641

3.  Quantitative structure-activity relationships by neural networks and inductive logic programming. II. The inhibition of dihydrofolate reductase by triazines.

Authors:  J D Hirst; R D King; M J Sternberg
Journal:  J Comput Aided Mol Des       Date:  1994-08       Impact factor: 3.686

Review 4.  Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.

Authors:  Takeshi Nishino; Ken Okamoto
Journal:  J Biol Inorg Chem       Date:  2014-12-12       Impact factor: 3.358
  4 in total

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