Literature DB >> 1245737

Clq inhibition of the interaction of collagen with human platelets.

J P Cazenave, S N Assimeh, R H Painter, M A Pachham, J F Mustard.   

Abstract

Human Clq, isolated in pure state after affinity chromatography on IgG-Sepharose, inhibited collagen-induced aggregation and release of 14C-Serotonin from prelabeled human platelets. Platelet aggregation induced by ADP or thrombin was not inhibited by Clq. Also, the adherence of platelets to glass surfaces was significantly diminished by Clq. In contrast, aggregated Clq mimicked the effect of collagen in causing platelet aggregation and release of serotonin. It appears that monomeric Clq, which has structural similarities to collagen competes with collagen for specific sites on the platelet surface.

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Year:  1976        PMID： 1245737

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  15 in total

1.  C1 and human platelets. III. Role of C1 subcomponents in platelet aggregation induced by aggregated IgG.

Authors:  J L Wautier; H Souchon; L C Solal; A P Peltier; J P Caen
Journal:  Immunology       Date:  1976-10       Impact factor: 7.397

2.  [Relations between complement and blood coagulation (author's transl)].

Authors:  G Müller-Berghaus
Journal:  Klin Wochenschr       Date:  1977-07-15

3.  Inhibition of the reconstitution of the haemolytic activity of the first component of human complement by a pepsin-derived fragment of subcomponent C1q.

Authors:  K B Reid; R B Sim; A P Faiers
Journal:  Biochem J       Date:  1977-02-01       Impact factor: 3.857

4.  Characterization of C1q-binding material released from the membranes of Raji and U937 cells by limited proteolysis with trypsin.

Authors:  A Erdei; K B Reid
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

5.  Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

Authors:  N C Hughes-Jones
Journal:  Immunology       Date:  1977-02       Impact factor: 7.397

Review 6.  The chemistry and biology of complement receptors.

Authors:  R D Schreiber
Journal:  Springer Semin Immunopathol       Date:  1984

Review 7.  Relationships among the complement, kinin, coagulation, and fibrinolytic systems.

Authors:  J S Sundsmo; D S Fair
Journal:  Springer Semin Immunopathol       Date:  1983

8.  Immunochemical quantitation of complement components of Clq and C3 in sera and synovial fluids of patients with bone and joint diseases.

Authors:  T Ochi; K Yonemasu; K Ono
Journal:  Ann Rheum Dis       Date:  1980-06       Impact factor: 19.103

9.  Identification of the Raji cell membrane-derived C1q inhibitor as a receptor for human C1q. Purification and immunochemical characterization.

Authors:  B Ghebrehiwet; L Silvestri; C McDevitt
Journal:  J Exp Med       Date:  1984-11-01       Impact factor: 14.307

10.  Similarities and dissimilarities between the binding ability of C1q and collagen.

Authors:  G Csákó; E A Suba; A Herp
Journal:  Clin Exp Immunol       Date:  1981-04       Impact factor: 4.330
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