[Relations between complement and blood coagulation (author's transl)].

The complement system as well as the blood coagulation system are involved in several disease processes so that it seems to be of interest to search for direct or indirect functional relations. Both systems can be activated in vitro as well as in vivo by the same substances, as e.g. endotoxin or antigen antibody complexes. In spite of these common characteristics a direct functional relationship between complement and plasmatic blood coagulation could not be established. Complement and blood coagulation do not interact with each other. Activated complement components, however, can induce platelet aggregation and release reaction both of which may accelerate but not trigger intravascular coagulation. Therefore, indirect relations between complement and blood coagulation can be found in patients or in animal experiments, especially after activation of intravascular coagulation. These interactions depend on further mediator sugstances of both systems.