Effects of callosal lesions in a model of letter perception.

During cognitive tasks, the cerebral hemispheres cooperate, compete, and in general, interact via the corpus callosum. Although behavioral studies in normal and split-brain subjects have revealed a great deal about the transcallosal exchange of information, a fundamental question remains unanswered and controversial: Are transcallosal interhemispheric influences primarily excitatory or inhibitory? In this context, we examined the effects of simulating sectioning of the corpus callosum in a computational model of visual letter recognition. Differences were found, following simulated callosal sectioning, in the performance of each individual hemisphere, in the mean activation levels of hemispheres, and in the specific patterns of activity, depending on the nature of the callosal influences. Together with other recent computational modeling results, the findings are most consistent with the hypothesis that transcallosal influences are predominantly excitatory, and they suggest measures that could be examined in future experimental studies to help resolve this issue.