Literature DB >> 12447467

Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases.

I A Pomytkin1, O E Kolesova.   

Abstract

We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H(2)O(2)that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H(2)O(2)and inactivation of liver protein tyrosine phosphatases.

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Year:  2002        PMID： 12447467     DOI： 10.1023/a:1020229724717

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

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3.  Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons.

Authors:  Tatiana P Storozhevykh; Yana E Senilova; Nadezhda A Persiyantseva; Vsevolod G Pinelis; Igor A Pomytkin
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5.  H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria.

Authors:  Igor A Pomytkin
Journal:  Curr Neuropharmacol       Date:  2012-12       Impact factor: 7.363

6.  Mitochondrial H2O2 as an enable signal for triggering autophosphorylation of insulin receptor in neurons.

Authors:  Nadezhda A Persiyantseva; Tatiana P Storozhevykh; Yana E Senilova; Lubov R Gorbacheva; Vsevolod G Pinelis; Igor A Pomytkin
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  6 in total

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