Literature DB >> 23395780

Manganese neurotoxicity and the role of reactive oxygen species.

Ebany J Martinez-Finley1, Claire E Gavin2, Michael Aschner3, Thomas E Gunter4.   

Abstract

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DA autoxidation; Free radicals; Manganese; Manganism; Mitochondrial dysfunction; Reactive oxygen species

Mesh：

Substances：

Year:  2013        PMID： 23395780      PMCID： PMC3713115          DOI： 10.1016/j.freeradbiomed.2013.01.032

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  191 in total

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7.  Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.

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8.  Nmr spectroscopic analysis of regional brain energy metabolism in manganese neurotoxicity.

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6.  Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes.

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7.  Alpha-synuclein oligomerization in manganese-induced nerve cell injury in brain slices: a role of NO-mediated S-nitrosylation of protein disulfide isomerase.

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Review 8.  Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson's Diseases.

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10.  Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration.

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