Literature DB >> 12445406

Growth signaling: TSC takes its place.

Steven J Marygold1, Sally J Leevers.   

Abstract

The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.

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Year:  2002        PMID： 12445406     DOI： 10.1016/s0960-9822(02)01294-0

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  22 in total

Review 1.  TOR pathway: linking nutrient sensing to life span.

Authors:  Pankaj Kapahi; Brian Zid
Journal:  Sci Aging Knowledge Environ       Date:  2004-09-08

2.  Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer.

Authors:  Christopher Johnson; Yuyan Han; Nathan Hughart; Jennifer McCarra; Gianfranco Alpini; Fanyin Meng
Journal:  Transl Gastrointest Cancer       Date:  2012-04-01

3.  The small GTPase Rheb is a key component linking amino acid signaling and TOR in the nutritional pathway that controls mosquito egg development.

Authors:  Saurabh G Roy; Alexander S Raikhel
Journal:  Insect Biochem Mol Biol       Date:  2010-10-28       Impact factor: 4.714

Review 4.  Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer.

Authors:  Hen Prizant; Stephen R Hammes
Journal:  Endocrinology       Date:  2016-07-13       Impact factor: 4.736

5.  A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation.

Authors:  Carmen M A Coelho; Benjamin Kolevski; Cherryl D Walker; Irene Lavagi; Thomas Shaw; Anselm Ebert; Sally J Leevers; Steven J Marygold
Journal:  Genetics       Date:  2005-07-05       Impact factor: 4.562

6.  Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM).

Authors:  Elena A Goncharova; Dmitry A Goncharov; Melane Fehrenbach; Irene Khavin; Blerina Ducka; Okio Hino; Thomas V Colby; Mervyn J Merrilees; Angela Haczku; Steven M Albelda; Vera P Krymskaya
Journal:  Sci Transl Med       Date:  2012-10-03       Impact factor: 17.956

Review 7.  p27 deregulation in breast cancer: prognostic significance and implications for therapy.

Authors:  A Alkarain; R Jordan; J Slingerland
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-01       Impact factor: 2.673

8.  mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.

Authors:  Mirei Murakami; Tomoko Ichisaka; Mitsuyo Maeda; Noriko Oshiro; Kenta Hara; Frank Edenhofer; Hiroshi Kiyama; Kazuyoshi Yonezawa; Shinya Yamanaka
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

9.  Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Authors:  Jose M Lizcano; Saif Alrubaie; Agnieszka Kieloch; Maria Deak; Sally J Leevers; Dario R Alessi
Journal:  Biochem J       Date:  2003-09-01       Impact factor: 3.857

Review 10.  Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

Authors:  Rongshi Li; Alan Pourpak; Stephan W Morris
Journal:  J Med Chem       Date:  2009-08-27       Impact factor: 7.446
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