Literature DB >> 12444682

Anti-HIV agents derived from the ent-kaurane diterpenoid linearol.

Maurizio Bruno1, Sergio Rosselli, Ivana Pibiri, Nicole Kilgore, Kuo-Hsiung Lee.   

Abstract

Twenty-six semisynthetic ent-kaurane derivatives of linearol (1) have been investigated for their anti-HIV effects. Five compounds (4, 7, 11, 25, and 26) showed significant activity against HIV replication in H9 lymphocyte cells with EC(50) values in the range <0.1-3.11 microg/mL. With TI values of 163 and 184, compounds 4 and 25 are especially promising for further development as potential anti-HIV agents.

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Year:  2002        PMID： 12444682     DOI： 10.1021/np020029b

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Cytotoxic geranylflavonoids from Bonannia graeca.

Authors:  Sergio Rosselli; Maurizio Bruno; Antonella Maggio; Rosa Angela Raccuglia; Muhammad Safder; Chin-Yu Lai; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Phytochemistry       Date:  2011-04-01       Impact factor: 4.072

2.  The enantioselective construction of tetracyclic diterpene skeletons with Friedel-Crafts alkylation and palladium-catalyzed cycloalkenylation reactions.

Authors:  Sarah J Burke; William P Malachowski; Sharan K Mehta; Roselyn Appenteng
Journal:  Org Biomol Chem       Date:  2015-03-07       Impact factor: 3.876

Review 3.  Genus Sideritis, section Empedoclia in southeastern Europe and Turkey - studies in ethnopharmacology and recent progress of biological activities.

Authors:  Ina Aneva; Peter Zhelev; Ekaterina Kozuharova; Kalina Danova; Seyed Fazel Nabavi; Sahar Behzad
Journal:  Daru       Date:  2019-03-30       Impact factor: 3.117

4.  Phytochemical Profile and Biological Activity of Endemic Sideritis sipylea Boiss. in North Aegean Greek Islands.

Authors:  Evangelos Axiotis; Eleftherios A Petrakis; Maria Halabalaki; Sofia Mitakou
Journal:  Molecules       Date:  2020-04-26       Impact factor: 4.411

5.  NMR-Based Chemical Profiling, Isolation and Evaluation of the Cytotoxic Potential of the Diterpenoid Siderol from Cultivated Sideritis euboea Heldr.

Authors:  Ekaterina-Michaela Tomou; Maria V Chatziathanasiadou; Paschalina Chatzopoulou; Andreas G Tzakos; Helen Skaltsa
Journal:  Molecules       Date:  2020-05-20       Impact factor: 4.411

6.  Pharmacophore based virtual screening for natural product database revealed possible inhibitors for SARS-COV-2 main protease.

Authors:  Mohamed K El-Ashrey; Riham O Bakr; Marwa A A Fayed; Rana H Refaey; Yassin M Nissan
Journal:  Virology       Date:  2022-03-22       Impact factor: 3.513
  6 in total

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