Literature DB >> 12441810

Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.

Becky Schweighardt1, Gabriel M Ortiz, Robert M Grant, Melissa Wellons, G Diego Miralles, Leondios G Kostrikis, John A Bartlett, Douglas F Nixon.   

Abstract

We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12441810     DOI： 10.1097/00002030-200211220-00018

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  11 in total

1.  Combination antiretroviral treatment for women previously treated only in pregnancy: week 24 results of AIDS clinical trials group protocol a5227.

Authors:  Mary A Vogler; Laura M Smeaton; Rodney L Wright; Sandra W Cardoso; Jorge Sanchez; Rosa Infante; Laura E Moran; Catherine Godfrey; Lisa M Demeter; Victoria A Johnson
Journal:  J Acquir Immune Defic Syndr       Date:  2014-04-15       Impact factor: 3.731

2.  The gut mucosal viral reservoir in HIV-infected patients is not the major source of rebound plasma viremia following interruption of highly active antiretroviral therapy.

Authors:  Paula Lerner; Moraima Guadalupe; Richard Donovan; Jason Hung; Jason Flamm; Thomas Prindiville; Sumathi Sankaran-Walters; Michael Syvanen; Joseph K Wong; Michael D George; Satya Dandekar
Journal:  J Virol       Date:  2011-02-23       Impact factor: 5.103

3.  CD4+ T-cell-guided structured treatment interruptions of antiretroviral therapy in HIV disease: projecting beyond clinical trials.

Authors:  Yazdan Yazdanpanah; Lindsey L Wolf; Xavier Anglaret; Delphine Gabillard; Rochelle P Walensky; Raoul Moh; Christine Danel; Caroline E Sloan; Elena Losina; Kenneth A Freedberg
Journal:  Antivir Ther       Date:  2010

4.  Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.

Authors:  Carmen de Mendoza; Ellen Paxinos; Pablo Barreiro; Nuria Camino; Marina Núñez; Vincent Soriano
Journal:  J Clin Microbiol       Date:  2004-02       Impact factor: 5.948

5.  CD4+ T-cell decline after the interruption of antiretroviral therapy in ACTG A5170 is predicted by differential expression of genes in the ras signaling pathway.

Authors:  Maryanne T Vahey; Zhining Wang; Zhaohui Su; Martin E Nau; Amy Krambrink; Daniel J Skiest; David M Margolis
Journal:  AIDS Res Hum Retroviruses       Date:  2008-08       Impact factor: 2.205

6.  Randomized, controlled trial of therapy interruption in chronic HIV-1 infection.

Authors:  Emmanouil Papasavvas; Jay R Kostman; Karam Mounzer; Robert M Grant; Robert Gross; Cele Gallo; Livio Azzoni; Andrea Foulkes; Brian Thiel; Maxwell Pistilli; Agnieszka Mackiewicz; Jane Shull; Luis J Montaner
Journal:  PLoS Med       Date:  2004-12-28       Impact factor: 11.069

7.  Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption.

Authors:  Suzy Maria; Evy Yunihastuti; Siti Rizny F Saldi; Zubairi Djoerban
Journal:  J Int Assoc Provid AIDS Care       Date:  2020 Jan-Dec

8.  Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen.

Authors:  Zoe Fox; Andrew Phillips; Cal Cohen; Jacquie Neuhaus; John Baxter; Sean Emery; Bernard Hirschel; Kathy Huppler Hullsiek; Christoph Stephan; Jens Lundgren
Journal:  AIDS       Date:  2008-11-12       Impact factor: 4.177

9.  Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections.

Authors:  Gavin C Sampey; Irene Guendel; Ravi Das; Elizabeth Jaworski; Zachary Klase; Aarthi Narayanan; Kylene Kehn-Hall; Fatah Kashanchi
Journal:  Biology (Basel)       Date:  2012-08-24

10.  Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men.

Authors:  Glenn-Milo Santos; Benjamin Ackerman; Amrita Rao; Sara Wallach; George Ayala; Erik Lamontage; Alex Garner; Ian W Holloway; Sonya Arreola; Vince Silenzio; Susanne Strömdahl; Louis Yu; Carol Strong; Tyler Adamson; Anna Yakusik; Tran Thu Doan; Poyao Huang; Damiano Cerasuolo; Amie Bishop; Teymur Noori; Anastasia Pharris; Max Aung; Masoud Dara; Ssu Yu Chung; Marguerite Hanley; Stefan Baral; Chris Beyrer; Sean Howell
Journal:  AIDS Behav       Date:  2021-02
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.