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Literature DB >> 1243984

Bioavailability of phenytoin. A comparison of two preparations.

M J Stewart, B R Ballinger, E J Devlin, A Y Miller, A C Ramsay.

Abstract

Plasma phenytoin levels were measured in 60 patients under steady-state conditions for a period of six weeks. During the trial, the preparation of phenytoin was changed from Phenytoin BP (Regent) to Epanutin Infatabs. A significant increase in plasma phenytoin levels following the change of tablet was matched by a decrease in the number of seizures.

Entities: Chemical Disease Species

Mesh：

Substances：
Tablets
Phenytoin

Year: 1975 PMID： 1243984 DOI： 10.1007/bf00614019

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

11 in total

1. Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.

Authors: W A DILL; A J GLAZKO; A KAZENKO; L M WOLF
Journal: J Pharmacol Exp Ther Date: 1956-11 Impact factor: 4.030

2. Clonazepam--a clinical study of its effectiveness as an anticonvulsant.

Authors: V E Edwards; M J Eadie
Journal: Proc Aust Assoc Neurol Date: 1973

3. Evaluation of a method of prescribing drugs in hospital, and a new method of recording their administration.

Authors: J Crooks; R D Weir; D C Coull; J W McNab; G Calder; J W Barnett; H B Caie
Journal: Lancet Date: 1967-03-25 Impact factor: 79.321

4. A comprehensive gas chromatographic scheme for the estimation of antiepileptic drugs.

Authors: C Gardner-Thorpe; M J Parsonage; P F Smethurst; C Toothill
Journal: Clin Chim Acta Date: 1972-01 Impact factor: 3.786

5. An evaluation of a drug administration system in a psychiatric hospital.

Authors: B R Ballinger; E Simpson; M J Stewart
Journal: Br J Psychiatry Date: 1974-08 Impact factor: 9.319

6. Drug estimation in the treatment of epilepsy.

Authors: A Richens
Journal: Proc R Soc Med Date: 1974-12

7. Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin.

Authors: L Lund
Journal: Eur J Clin Pharmacol Date: 1974 Impact factor: 2.953

8. Factors involved in an outbreak of phenytoin intoxication.

Authors: F Bochner; W D Hooper; J H Tyrer; M J Eadie
Journal: J Neurol Sci Date: 1972-08 Impact factor: 3.181

9. The effect of phenobarbital on plasma diphenylhydantoin level and metabolism in man and in rat liver microsomes.

Authors: H Kutt; J Haynes; K Verebely; F McDowell
Journal: Neurology Date: 1969-06 Impact factor: 9.910

10. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man.

Authors: J M Hansen; K Siersboek-Nielsen; L Skovsted
Journal: Clin Pharmacol Ther Date: 1971 May-Jun Impact factor: 6.875

9 in total

Review 1. Is generic prescribing acceptable in epilepsy?

Authors: F M Besag
Journal: Drug Saf Date: 2000-09 Impact factor: 5.606

2. A comparison between microcrystalline and conventional phenytoin preparations: relative bioavailability and steady-state plasma concentrations.

Authors: L O Boréus; A Nergårdh; M Ehrnebo; K Theorell
Journal: J Neurol Date: 1980 Impact factor: 4.849

Bioavailability of phenytoin. A comparison of two preparations.

1. Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.

2. Clonazepam--a clinical study of its effectiveness as an anticonvulsant.

3. Evaluation of a method of prescribing drugs in hospital, and a new method of recording their administration.

4. A comprehensive gas chromatographic scheme for the estimation of antiepileptic drugs.

5. An evaluation of a drug administration system in a psychiatric hospital.

6. Drug estimation in the treatment of epilepsy.

7. Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin.

8. Factors involved in an outbreak of phenytoin intoxication.

9. The effect of phenobarbital on plasma diphenylhydantoin level and metabolism in man and in rat liver microsomes.

10. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man.

Review 1. Is generic prescribing acceptable in epilepsy?

2. A comparison between microcrystalline and conventional phenytoin preparations: relative bioavailability and steady-state plasma concentrations.

3. A comparison of the bioavailability of two brands of phenytoin.

4. Rate of phenytoin accumulation in man: a simulation study.

5. Influence of food on the absorption of phenytoin in man.

6. Bioavailability and dissolution of proprietary and generic formulations of phenytoin.

7. Impact of generic substitution of anticonvulsants on the treatment of epilepsy.

8. Bioavailability of three phenytoin preparations in healthy subjects and in epileptics.

Review 9. Clinical pharmacokinetics of phenytoin.