C Charlier1, C l Desaive, G Plomteux. 1. Clinical Toxicology Laboratory, University Hospital, Liege, Belgium. c.charlier@chu.ulg.ac.be
Abstract
BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters). DESIGN: Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people. MEASUREMENTS: Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry. RESULTS: The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants. CONCLUSION: Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.
BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters). DESIGN: Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people. MEASUREMENTS: Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry. RESULTS: The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants. CONCLUSION: Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.
Authors: Mary L Biggs; Mark D Davis; David L Eaton; Noel S Weiss; Dana B Barr; David R Doody; Sherianne Fish; Larry L Needham; Chu Chen; Stephen M Schwartz Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-08 Impact factor: 4.254
Authors: Penelope J E Quintana; Ralph J Delfino; Susan Korrick; Argyrios Ziogas; Frederick W Kutz; Ellen L Jones; Francine Laden; Eric Garshick Journal: Environ Health Perspect Date: 2004-06 Impact factor: 9.031
Authors: Lesa L Aylward; James J Collins; Kenneth M Bodner; Michael Wilken; Catherine M Bodnar Journal: Environ Health Perspect Date: 2012-10-11 Impact factor: 9.031