Literature DB >> 12438604

A cis-acting element that directs circular adeno-associated virus replication and packaging.

Sergei Musatov1, Jill Roberts, Donald Pfaff, Michael Kaplitt.   

Abstract

A novel pathway of adeno-associated virus (AAV) replication marked by the assembly of circular monomer duplex intermediates (cAAV) has been recently discovered. In the present report we identify a single AD domain of the inverted terminal repeat as a minimal origin of cAAV replication. A small internal palindrome (BB'), necessary for optimal Rep-inverted terminal repeat interaction, does not contribute to the efficiency of cAAV replication, while the terminal resolution site is an essential cis-acting element. Furthermore, recombinant cAAV vectors that encompass only the AD domain replicate exclusively in a circular form and no detectable linear duplex replicative intermediates are generated, suggesting that both pathways of AAV replication are independent and can be separated. In addition, we show that cAAVs are efficient templates for encapsidation of single-stranded DNA genomes, an observation that assigns a biological role for these novel replication species. Together, these findings shed new light on the current model of AAV replication and packaging.

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Year:  2002        PMID： 12438604      PMCID： PMC136660          DOI： 10.1128/jvi.76.24.12792-12802.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  49 in total

1.  Mechanism of Rep-mediated adeno-associated virus origin nicking.

Authors:  J R Brister; N Muzyczka
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome.

Authors:  G Chadeuf; D Favre; J Tessier; N Provost; P Nony; J Kleinschmidt; P Moullier; A Salvetti
Journal:  J Gene Med       Date:  2000 Jul-Aug       Impact factor: 4.565

3.  An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA.

Authors:  R H Smith; R M Kotin
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

4.  Induction of circular episomes during rescue and replication of adeno-associated virus in experimental models of virus latency.

Authors:  S A Musatov; T A Scully; L Dudus; K J Fisher
Journal:  Virology       Date:  2000-09-30       Impact factor: 3.616

5.  Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions.

Authors:  X S Wang; S Ponnazhagan; A Srivastava
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

6.  A helper virus-free packaging system for recombinant adeno-associated virus vectors.

Authors:  R F Collaco; X Cao; J P Trempe
Journal:  Gene       Date:  1999-10-01       Impact factor: 3.688

7.  Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein.

Authors:  E Urcelay; P Ward; S M Wiener; B Safer; R M Kotin
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

8.  Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification.

Authors:  J R Brister; N Muzyczka
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

9.  Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors.

Authors:  F K Ferrari; T Samulski; T Shenk; R J Samulski
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

10.  Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.

Authors:  K J Fisher; G P Gao; M D Weitzman; R DeMatteo; J F Burda; J M Wilson
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103
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  19 in total

1.  Palindrome regeneration by template strand-switching mechanism at the origin of DNA replication of porcine circovirus via the rolling-circle melting-pot replication model.

Authors:  Andrew K Cheung
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

2.  Nanopore sequencing of native adeno-associated virus (AAV) single-stranded DNA using a transposase-based rapid protocol.

Authors:  Marco T Radukic; David Brandt; Markus Haak; Kristian M Müller; Jörn Kalinowski
Journal:  NAR Genom Bioinform       Date:  2020-09-28

3.  Characterization of adeno-associated virus genomes isolated from human tissues.

Authors:  Bruce C Schnepp; Ryan L Jensen; Chun-Liang Chen; Philip R Johnson; K Reed Clark
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

4.  Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.

Authors:  Daniel L Glauser; Okay Saydam; N Alexander Balsiger; Irma Heid; R Michael Linden; Mathias Ackermann; Cornel Fraefel
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

5.  The cellular TATA binding protein is required for rep-dependent replication of a minimal adeno-associated virus type 2 p5 element.

Authors:  Achille François; Mickaël Guilbaud; Rafi Awedikian; Gilliane Chadeuf; Philippe Moullier; Anna Salvetti
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

6.  Herpes simplex virus type 1/adeno-associated virus hybrid vectors.

Authors:  Anna Paula de Oliveira; Cornel Fraefel
Journal:  Open Virol J       Date:  2010-06-18

7.  Relative influence of the adeno-associated virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration.

Authors:  Mickaël Guilbaud; Gilliane Chadeuf; Fabio Avolio; Achille François; Philippe Moullier; Alessandra Recchia; Anna Salvetti
Journal:  J Virol       Date:  2007-12-19       Impact factor: 5.103

8.  Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity.

Authors:  Qinghao Xu; Sandra M Garraway; Amanda R Weyerbacher; Sarah J Shin; Charles E Inturrisi
Journal:  J Neurosci       Date:  2008-12-24       Impact factor: 6.167

9.  The genome of human parvovirus b19 can replicate in nonpermissive cells with the help of adenovirus genes and produces infectious virus.

Authors:  Wuxiang Guan; Susan Wong; Ning Zhi; Jianming Qiu
Journal:  J Virol       Date:  2009-07-08       Impact factor: 5.103

10.  Detection of template strand switching during initiation and termination of DNA replication of porcine circovirus.

Authors:  Andrew K Cheung
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103
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