Literature DB >> 18094174

Relative influence of the adeno-associated virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration.

Mickaël Guilbaud1, Gilliane Chadeuf, Fabio Avolio, Achille François, Philippe Moullier, Alessandra Recchia, Anna Salvetti.   

Abstract

The p5 promoter region of the adeno-associated virus type 2 (AAV-2) rep gene has been described as essential for Rep-mediated site-specific integration (RMSSI) of plasmid sequences in human chromosome 19. We report here that insertion of a full-length or minimal p5 element between the viral inverted terminal repeats does not significantly increase RMSSI of a recombinant AAV (rAAV) vector after infection of growth-arrested or proliferating human cells. This result suggests that the p5 element may not improve RMSSI of rAAV vectors in vivo.

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Year:  2007        PMID： 18094174      PMCID： PMC2258927          DOI： 10.1128/JVI.01956-07

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  Adeno-associated virus site-specifically integrates into a muscle-specific DNA region.

Authors:  N Dutheil; F Shi; T Dupressoir; R M Linden
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

2.  Efficient replication of adeno-associated virus type 2 vectors: a cis-acting element outside of the terminal repeats and a minimal size.

Authors:  G E Tullis; T Shenk
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences.

Authors:  P Nony; J Tessier; G Chadeuf; P Ward; A Giraud; M Dugast; R M Linden; P Moullier; A Salvetti
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

4.  Infection of a human hepatoma cell line by hepatitis B virus.

Authors:  Philippe Gripon; Sylvie Rumin; Stephan Urban; Jacques Le Seyec; Denise Glaise; Isabelle Cannie; Claire Guyomard; Josette Lucas; Christian Trepo; Christiane Guguen-Guillouzo
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-13       Impact factor: 11.205

5.  Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.

Authors:  Nicola J Philpott; Catherine Giraud-Wali; Carolyn Dupuis; Janette Gomos; Henry Hamilton; Kenneth I Berns; Erik Falck-Pedersen
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

6.  Adeno-associated virus type 2 p5 promoter: a rep-regulated DNA switch element functioning in transcription, replication, and site-specific integration.

Authors:  Mary Murphy; Janette Gomos-Klein; Marko Stankic; Erik Falck-Pedersen
Journal:  J Virol       Date:  2007-01-31       Impact factor: 5.103

7.  Adeno-associated virus integrates site-specifically into human chromosome 19 in either orientation and with equal kinetics and frequency.

Authors:  Daniela Hüser; Regine Heilbronn
Journal:  J Gen Virol       Date:  2003-01       Impact factor: 3.891

8.  A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.

Authors:  Nicola J Philpott; Janette Gomos; Kenneth I Berns; Erik Falck-Pedersen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

9.  Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors.

Authors:  Alessandra Recchia; Laura Perani; Daniela Sartori; Clelia Olgiati; Fulvio Mavilio
Journal:  Mol Ther       Date:  2004-10       Impact factor: 11.454

10.  Kinetics and frequency of adeno-associated virus site-specific integration into human chromosome 19 monitored by quantitative real-time PCR.

Authors:  Daniela Hüser; Stefan Weger; Regine Heilbronn
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103
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  2 in total

1.  Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1.

Authors:  Rachel Millet; Nelly Jolinon; Xuan-Nhi Nguyen; Gregory Berger; Andrea Cimarelli; Anna Greco; Pascale Bertrand; Margarete Odenthal; Hildegard Büning; Anna Salvetti
Journal:  J Virol       Date:  2015-04-22       Impact factor: 5.103

2.  Non-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics.

Authors:  Gwendolyn M Wilmes; Kimberly L Carey; Stuart W Hicks; Hugh H Russell; Jesse A Stevenson; Paulina Kocjan; Stephen R Lutz; Rachel S Quesenberry; Sergey V Shulga-Morskoy; Megan E Lewis; Ethan Clark; Violetta Medik; Anthony B Cooper; Elizabeth E Reczek
Journal:  MAbs       Date:  2014-04-23       Impact factor: 5.857
  2 in total

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