Literature DB >> 12438394

Construction of an Actinobacillus pleuropneumoniae serotype 2 prototype live negative-marker vaccine.

Walaiporn Tonpitak1, Nina Baltes, Isabel Hennig-Pauka, Gerald F Gerlach.   

Abstract

Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol application, and facilitates the serological discrimination of immunized and infected herds.

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Year:  2002        PMID： 12438394      PMCID： PMC133062          DOI： 10.1128/IAI.70.12.7120-7125.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Evaluation of an indirect enzyme-linked immunosorbent assay (ELISA) for detection of antibodies to the Apx toxins of Actinobacillus pleuropneumoniae.

Authors:  R Nielsen; J F van den Bosch; T Plambeck; V Sørensen; J P Nielsen
Journal:  Vet Microbiol       Date:  2000-01       Impact factor: 3.293

2.  Imperfect vaccines and the evolution of pathogen virulence.

Authors:  S Gandon; M J Mackinnon; S Nee; A F Read
Journal:  Nature       Date:  2001-12-13       Impact factor: 49.962

3.  Actinobacillus (Haemophilus) pleuropneumoniae infections in swine: serological investigations and vaccination trials in combination with environmental improvements.

Authors:  P Beskow; O Söderlind; B Thafvelin
Journal:  Zentralbl Veterinarmed B       Date:  1989-09

4.  Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection.

Authors:  Nina Baltes; Isabel Hennig-Pauka; Gerald-F Gerlach
Journal:  FEMS Microbiol Lett       Date:  2002-04-09       Impact factor: 2.742

5.  Antimicrobial susceptibility and plasmid analysis of Actinobacillus pleuropneumoniae isolated in Taiwan.

Authors:  Chao Fu Chang; Tung Mao Yeh; Chin Cheng Chou; Yung Fu Chang; Tai Sheng Chiang
Journal:  Vet Microbiol       Date:  2002-01-03       Impact factor: 3.293

6.  Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response.

Authors:  N Baltes; W Tonpitak; G F Gerlach; I Hennig-Pauka; A Hoffmann-Moujahid; M Ganter; H J Rothkötter
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

7.  A novel strategy for protective Actinobacillus pleuropneumoniae subunit vaccines: detergent extraction of cultures induced by iron restriction.

Authors:  R Goethe; O F Gonzáles; T Lindner; G F Gerlach
Journal:  Vaccine       Date:  2000-11-22       Impact factor: 3.641

8.  Pigs aerogenously immunized with genetically inactivated (ghosts) or irradiated Actinobacillus pleuropneumoniae are protected against a homologous aerosol challenge despite differing in pulmonary cellular and antibody responses.

Authors:  A Katinger; W Lubitz; M P Szostak; M Stadler; R Klein; A Indra; V Huter; A Hensel
Journal:  J Biotechnol       Date:  1999-08-20       Impact factor: 3.307

Review 9.  [Zoonoses control--new challenges in health protection of consumers].

Authors:  D Grossklaus
Journal:  Berl Munch Tierarztl Wochenschr       Date:  2001 Nov-Dec       Impact factor: 0.328

10.  Tylosin tartrate and tiamutilin effects on experimental piglet pneumonia induced with pneumonic pig lung homogenate containing mycoplasmas, bacteria and viruses.

Authors:  P C Hannan; B S Bhogal; J P Fish
Journal:  Res Vet Sci       Date:  1982-07       Impact factor: 2.534
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  11 in total

1.  Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence.

Authors:  Ilse Jacobsen; Isabel Hennig-Pauka; Nina Baltes; Matthias Trost; Gerald-F Gerlach
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

2.  Use of an Actinobacillus pleuropneumoniae multiple mutant as a vaccine that allows differentiation of vaccinated and infected animals.

Authors:  Alexander Maas; Ilse D Jacobsen; Jochen Meens; Gerald-F Gerlach
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

3.  Deletion of the anaerobic regulator HlyX causes reduced colonization and persistence of Actinobacillus pleuropneumoniae in the porcine respiratory tract.

Authors:  Nina Baltes; Mohamed N'diaye; Ilse D Jacobsen; Alexander Maas; Falk F R Buettner; Gerald-F Gerlach
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

4.  Identification of QTL affecting resistance/susceptibility to acute Actinobacillus pleuropneumoniae infection in swine.

Authors:  Gerald Reiner; Natalie Bertsch; Doris Hoeltig; Martin Selke; Hermann Willems; Gerald Friedrich Gerlach; Burkhard Tuemmler; Inga Probst; Ralf Herwig; Mario Drungowski; Karl Heinz Waldmann
Journal:  Mamm Genome       Date:  2014-01-21       Impact factor: 2.957

5.  Link between Heterotrophic Carbon Fixation and Virulence in the Porcine Lung Pathogen Actinobacillus pleuropneumoniae.

Authors:  Sarah A Konze; Wolf-Rainer Abraham; Elke Goethe; Esther Surges; Marcel M M Kuypers; Doris Hoeltig; Jochen Meens; Charlotte Vogel; Meike Stiesch; Peter Valentin-Weigand; Gerald-F Gerlach; Falk F R Buettner
Journal:  Infect Immun       Date:  2019-08-21       Impact factor: 3.441

6.  Pathway deregulation and expression QTLs in response to Actinobacillus pleuropneumoniae infection in swine.

Authors:  Gerald Reiner; Felix Dreher; Mario Drungowski; Doris Hoeltig; Natalie Bertsch; Martin Selke; Hermann Willems; Gerald Friedrich Gerlach; Inga Probst; Burkhardt Tuemmler; Karl-Heinz Waldmann; Ralf Herwig
Journal:  Mamm Genome       Date:  2014-08-14       Impact factor: 2.957

7.  Characterization of the antigenic lipopolysaccharide O chain and the capsular polysaccharide produced by Actinobacillus pleuropneumoniae serotype 13.

Authors:  Leann L MacLean; Malcolm B Perry; Evguenii Vinogradov
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

8.  Identification of dimethyl sulfoxide reductase in Actinobacillus pleuropneumoniae and its role in infection.

Authors:  Nina Baltes; Isabel Hennig-Pauka; Ilse Jacobsen; Achim D Gruber; Gerald F Gerlach
Journal:  Infect Immun       Date:  2003-12       Impact factor: 3.441

9.  The generation of successive unmarked mutations and chromosomal insertion of heterologous genes in Actinobacillus pleuropneumoniae using natural transformation.

Authors:  Janine T Bossé; Denise M Soares-Bazzolli; Yanwen Li; Brendan W Wren; Alexander W Tucker; Duncan J Maskell; Andrew N Rycroft; Paul R Langford
Journal:  PLoS One       Date:  2014-11-19       Impact factor: 3.240

10.  Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice.

Authors:  Sung Jae Shin; Seung Won Shin; Mi Lan Kang; Deog Yong Lee; Moon-Sik Yang; Yong-Suk Jang; Han Sang Yoo
Journal:  J Vet Sci       Date:  2007-12       Impact factor: 1.672
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