Literature DB >> 12433976

Transport of xenobiotics across the blood-brain barrier.

Bruno Hagenbuch1, Bo Gao, Peter J Meier.   

Abstract

Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.

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Year:  2002        PMID： 12433976     DOI： 10.1152/nips.01402.2002

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  17 in total

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Review 2.  Physiology, structure, and regulation of the cloned organic anion transporters.

Authors:  C Srimaroeng; J L Perry; J B Pritchard
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Review 3.  Modeling kinetics of subcellular disposition of chemicals.

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Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

Review 4.  In vitro blood-brain barrier models: current and perspective technologies.

Authors:  Pooja Naik; Luca Cucullo
Journal:  J Pharm Sci       Date:  2011-12-27       Impact factor: 3.534

5.  (125)I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells.

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Journal:  Nucl Med Biol       Date:  2014-11-08       Impact factor: 2.408

6.  Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptides.

Authors:  Zeljko Radulović; Lindsay M Porter; Tae K Kim; Albert Mulenga
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Review 7.  Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments.

Authors:  Thomas W McAllister; Tim A Ahles; Andrew J Saykin; Robert J Ferguson; Brenna C McDonald; Lionel D Lewis; Laura A Flashman; C Harker Rhodes
Journal:  Curr Psychiatry Rep       Date:  2004-10       Impact factor: 5.285

8.  Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.

Authors:  Iman A Elkiweri; Yan Ling Zhang; Uwe Christians; Ka-Yun Ng; Martha C Tissot van Patot; Thomas K Henthorn
Journal:  Anesth Analg       Date:  2009-01       Impact factor: 5.108

9.  Endothelin-1 reduces p-glycoprotein transport activity in an in vitro model of human adult blood-brain barrier.

Authors:  Alexandra Hembury; Aloïse Mabondzo
Journal:  Cell Mol Neurobiol       Date:  2008-04-01       Impact factor: 5.046

10.  Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Authors:  Amber Dahlin; Ethan Geier; Sophie L Stocker; Cheryl D Cropp; Elena Grigorenko; Michele Bloomer; Julie Siegenthaler; Lu Xu; Anthony S Basile; Diane D-S Tang-Liu; Kathleen M Giacomini
Journal:  Mol Pharm       Date:  2013-01-24       Impact factor: 4.939
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