Literature DB >> 12433763

Effect of iron supplementation on incidence of infectious illness in children: systematic review.

Tarun Gera1, H P S Sachdev.   

Abstract

OBJECTIVE: To evaluate the effect of iron supplementation on the incidence of infections in children.
DESIGN: Systematic review of randomised controlled trials. DATA SOURCES: 28 randomised controlled trials (six unpublished and 22 published) on 7892 children.
INTERVENTIONS: Oral or parenteral iron supplementation or fortified formula milk or cereals. OUTCOMES: Incidence of all recorded infectious illnesses, and individual illnesses, including respiratory tract infection, diarrhoea, malaria, other infections, and prevalence of positive smear results for malaria.
RESULTS: The pooled estimate (random effects model) of the incidence rate ratio (iron v placebo) was 1.02 (95% confidence interval 0.96 to 1.08, P=0.54; P<0.0001 for heterogeneity). The incidence rate difference (iron minus placebo) for all recorded illnesses was 0.06 episodes/child year (-0.06 to 0.18, P=0.34; P<0.0001 for heterogeneity). However, there was an increase in the risk of developing diarrhoea (incidence rate ratio 1.11, 1.01 to 1.23, P=0.04), but this would not have an overall important on public health (incidence rate difference 0.05 episodes/child year, -0.03 to 0.13; P=0.21). The occurrence of other illnesses and positive results on malaria smears (adjusted for positive smears at baseline) were not significantly affected by iron administration. On meta-regression, the statistical heterogeneity could not be explained by the variables studied.
CONCLUSION: Iron supplementation has no apparent harmful effect on the overall incidence of infectious illnesses in children, though it slightly increases the risk of developing diarrhoea.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12433763      PMCID: PMC133452          DOI: 10.1136/bmj.325.7373.1142

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


  45 in total

Review 1.  Iron and its relation to immunity and infectious disease.

Authors:  S J Oppenheimer
Journal:  J Nutr       Date:  2001-02       Impact factor: 4.798

Review 2.  The role of iron in bacterial infections, with special consideration of host-tubercle bacillus interaction.

Authors:  I Kochan
Journal:  Curr Top Microbiol Immunol       Date:  1973       Impact factor: 4.291

3.  Iron deficiency anemia of infancy: some clinical principles illustrated by the response of Maori infants to neonatal parenteral iron administration.

Authors:  R J Cantwell
Journal:  Clin Pediatr (Phila)       Date:  1972-08       Impact factor: 1.168

4.  Iron supplementation of the diet in full-term infants: a controlled study.

Authors:  J H Fuerth
Journal:  J Pediatr       Date:  1972-06       Impact factor: 4.406

5.  Haemoglobin levels in normal infants aged 3 to 24 months, and the effect of iron.

Authors:  D Burman
Journal:  Arch Dis Child       Date:  1972-04       Impact factor: 3.791

6.  Side-effects of oral iron therapy. A double-blind study of different iron compounds in tablet form.

Authors:  L Hallberg; L Ryttinger; L Sölvell
Journal:  Acta Med Scand Suppl       Date:  1966

7.  Utilization of dietary iron by term infants. A study of 1,048 infants from a low socioeconomic population.

Authors:  M B Andelman; B R Sered
Journal:  Am J Dis Child       Date:  1966-01

8.  Altered anti-oxidant status and increased lipid peroxidation in marasmic children.

Authors:  M M Tatli; H Vural; A Koc; M Kosecik; A Atas
Journal:  Pediatr Int       Date:  2000-06       Impact factor: 1.524

9.  Clinical safety of iron-fortified formulas.

Authors:  A Singhal; R Morley; R Abbott; S Fairweather-Tait; T Stephenson; A Lucas
Journal:  Pediatrics       Date:  2000-03       Impact factor: 7.124

10.  Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6-36 month old Togolese children.

Authors:  J Berger; J L Dyck; P Galan; A Aplogan; D Schneider; P Traissac; S Hercberg
Journal:  Eur J Clin Nutr       Date:  2000-01       Impact factor: 4.016

View more
  78 in total

1.  Improving iron status in children in poor environments.

Authors:  Andrew Tomkins
Journal:  BMJ       Date:  2002-11-16

2.  Micronutrient supplementation and child survival in India.

Authors:  Prakash V Kotecha; Chandrakant Lahariya
Journal:  Indian J Pediatr       Date:  2010-03-19       Impact factor: 1.967

3.  Evidence-based clinical guidelines for immigrants and refugees.

Authors:  Kevin Pottie; Christina Greenaway; John Feightner; Vivian Welch; Helena Swinkels; Meb Rashid; Lavanya Narasiah; Laurence J Kirmayer; Erin Ueffing; Noni E MacDonald; Ghayda Hassan; Mary McNally; Kamran Khan; Ralf Buhrmann; Sheila Dunn; Arunmozhi Dominic; Anne E McCarthy; Anita J Gagnon; Cécile Rousseau; Peter Tugwell
Journal:  CMAJ       Date:  2010-06-07       Impact factor: 8.262

4.  Haematological effect of iron supplementation in breast fed term low birth weight infants.

Authors:  D Aggarwal; H P S Sachdev; J Nagpal; T Singh; V Mallika
Journal:  Arch Dis Child       Date:  2005-01       Impact factor: 3.791

5.  Reporting of systematic reviews of micronutrients and health: a critical appraisal.

Authors:  Mei Chung; Ethan M Balk; Stanley Ip; Gowri Raman; Winifred W Yu; Thomas A Trikalinos; Alice H Lichtenstein; Elizabeth A Yetley; Joseph Lau
Journal:  Am J Clin Nutr       Date:  2009-02-25       Impact factor: 7.045

6.  Dietary Iron Deficiency and Oversupplementation Increase Intestinal Permeability, Ion Transport, and Inflammation in Pigs.

Authors:  Yihang Li; Stephanie L Hansen; Luke B Borst; Jerry W Spears; Adam J Moeser
Journal:  J Nutr       Date:  2016-06-29       Impact factor: 4.798

7.  The effects of micronutrient deficiencies on bacterial species from the human gut microbiota.

Authors:  Matthew C Hibberd; Meng Wu; Dmitry A Rodionov; Xiaoqing Li; Jiye Cheng; Nicholas W Griffin; Michael J Barratt; Richard J Giannone; Robert L Hettich; Andrei L Osterman; Jeffrey I Gordon
Journal:  Sci Transl Med       Date:  2017-05-17       Impact factor: 17.956

8.  Dynamic control of hepatic Plasmodium numbers by hepcidin despite elevated liver iron during iron supplementation.

Authors:  Patricia Ferrer; Ricardo Castillo-Neyra; Cindy N Roy; David J Sullivan
Journal:  Microbes Infect       Date:  2015-09-15       Impact factor: 2.700

Review 9.  Safety of iron fortification and supplementation in malaria-endemic areas.

Authors:  Gary M Brittenham
Journal:  Nestle Nutr Inst Workshop Ser       Date:  2012

10.  Low iron availability in continuous in vitro colonic fermentations induces strong dysbiosis of the child gut microbial consortium and a decrease in main metabolites.

Authors:  Alexandra Dostal; Sophie Fehlbaum; Christophe Chassard; Michael B Zimmermann; Christophe Lacroix
Journal:  FEMS Microbiol Ecol       Date:  2012-08-28       Impact factor: 4.194

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.