Literature DB >> 12433044

Microwave-assisted (radio)halogenation of nitroimidazole-based hypoxia markers.

P Kumar1, L I Wiebe, M Asikoglu, M Tandon, A J B McEwan.   

Abstract

Microwave-assisted radiohalogenation for the production of short-lived radiopharmaceuticals has now been applied to the synthesis and radiolabelling of azomycin nucleosides. (Radio)halogens were incorporated either by nucleophilic substitution of a leaving group or by halogen-halogen exchange, in the synthesis of IAZA, IAZP and FAZA. A comparison of conventional labelling and microwave-assisted labelling procedures reflects a clear advantage of the microwave technique.

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Year:  2002        PMID： 12433044     DOI： 10.1016/s0969-8043(02)00185-9

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  7 in total

1.  A remote controlled system for the preparation of 7 alpha-[18F]fluoro-17 alpha-methyl 5 alpha-dihydrotestosterone ([18F]FMDHT) using microwave.

Authors:  Sudha Garg; Andrew J H Lynch; Aniruddha K Doke; Richard C Minton; Pradeep K Garg
Journal:  Appl Radiat Isot       Date:  2008-02-13       Impact factor: 1.513

Review 2.  Kinetic modeling in PET imaging of hypoxia.

Authors:  Fan Li; Jesper T Joergensen; Anders E Hansen; Andreas Kjaer
Journal:  Am J Nucl Med Mol Imaging       Date:  2014-09-06

3.  Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

Authors:  Xia Shao; Raphaël Hoareau; Brian G Hockley; Louis J M Tluczek; Bradford D Henderson; Henry C Padgett; Peter J H Scott
Journal:  J Labelled Comp Radiopharm       Date:  2011-05-30       Impact factor: 1.921

4.  Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

Authors:  Marek Pruszyński; Aleksander Bilewicz; Michael R Zalutsky
Journal:  Bioconjug Chem       Date:  2008-03-14       Impact factor: 4.774

5.  Tumour hypoxia imaging with [18F]FAZA PET in head and neck cancer patients: a pilot study.

Authors:  M Souvatzoglou; A L Grosu; B Röper; B J Krause; R Beck; G Reischl; M Picchio; H-J Machulla; H-J Wester; M Piert
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-04-20       Impact factor: 9.236

6.  Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

Authors:  Makiko Suehiro; Paul Burgman; Sean Carlin; Sean Burke; Guangbin Yang; Ouathek Ouerfelli; Christoph Oehler-Janne; Joseph O'Donoghue; Clifton Ling; John Humm
Journal:  Nucl Med Biol       Date:  2009-05-07       Impact factor: 2.408

7.  Preparation of nucleosides derived from 2-nitroimidazole and D-arabinose, D-ribose, and D-galactose by the Vorbrüggen method and their conversion to potential precursors for tracers to image hypoxia.

Authors:  Anna Schweifer; Friedrich Hammerschmidt
Journal:  J Org Chem       Date:  2011-09-09       Impact factor: 4.354
  7 in total

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