Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible.

In the linakge analysis of quantitative traits, an additive model that assumes no dominance effect is often adopted. Intuitively, when the no-dominance-effect assumption does not hold, such a practice does not make efficient use of the data, and its power to detect linkage can be improved. Here we introduce a score statistic for detecting quantitative trait loci when the dominance effect is not neglible or the dominance effect is a concern. This statistic is derived from a normal likelihood function for sibships of arbitrary size. In the derivation, the inherent genetic constraints on model parameters are fully taken into consideration. This score statistic is asymptotically equivalent to the corresponding likelihood ratio statistic, but it is much easier to compute. The asymptotic distribution of this statistic is derived, which is a mixture of chi(0) (2), chi(1) (2), and chi(2) (2). Weights for distribution components are functions of the informativeness of the marker data. The type I error rate and the power of the proposed statistic in finite sample are evaluated via simulations. Copyright 2002 Wiley-Liss, Inc.