| Literature DB >> 12432060 |
Matthias Krause1, James E Bear, Joseph J Loureiro, Frank B Gertler.
Abstract
Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.Entities:
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Year: 2002 PMID: 12432060 DOI: 10.1242/jcs.00218
Source DB: PubMed Journal: J Cell Sci ISSN: 0021-9533 Impact factor: 5.285