Literature DB >> 12430452

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

Melanie J Calvert1, Susan E Taylor, Rudolf K Allemann.   

Abstract

A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic beta-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.

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Year:  2002        PMID： 12430452     DOI： 10.1039/b206517g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

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Journal:  Chem Rev       Date:  2017-08-25       Impact factor: 60.622

2.  Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.

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Authors:  Xinyu Liu; Christopher T Walsh
Journal:  Biochemistry       Date:  2009-11-24       Impact factor: 3.162

4.  Synthetic efficiency in enzyme mechanisms involving carbocations: aristolochene synthase.

Authors:  Rudolf K Allemann; Neil J Young; Shuhua Ma; Donald G Truhlar; Jiali Gao
Journal:  J Am Chem Soc       Date:  2007-10-05       Impact factor: 15.419

5.  Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase.

Authors:  Marianna Loizzi; David J Miller; Rudolf K Allemann
Journal:  Org Biomol Chem       Date:  2019-01-31       Impact factor: 3.876

6.  Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.

Authors:  Juan A Faraldos; Yuxin Zhao; Paul E O'Maille; Joseph P Noel; Robert M Coates
Journal:  Chembiochem       Date:  2007-10-15       Impact factor: 3.164

7.  Optimising Terpene Synthesis with Flow Biocatalysis.

Authors:  Xiaoping Tang; Rudolf K Allemann; Thomas Wirth
Journal:  European J Org Chem       Date:  2017-01-13

8.  Nucleophilic Water Capture or Proton Loss: Single Amino Acid Switch Converts δ-Cadinene Synthase into Germacradien-4-ol Synthase.

Authors:  Marianna Loizzi; Veronica González; David J Miller; Rudolf K Allemann
Journal:  Chembiochem       Date:  2017-11-23       Impact factor: 3.164
  8 in total

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