Literature DB >> 12427796

Functional heartburn: the stimulus, the pain, and the brain.

R Fass1, G Tougas.   

Abstract

Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present. The mechanisms responsible for pain, clinical characteristics, and the optimal therapeutic approach remain poorly understood. Response to potent antireflux treatment is relatively limited. Current and future treatment strategies for functional heartburn patients who have failed standard dose proton pump inhibitors (PPIs) include increased PPI dose in some, as well as addition of pain modulators in others.

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Year:  2002        PMID： 12427796      PMCID： PMC1773475          DOI： 10.1136/gut.51.6.885

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  52 in total

1.  Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux--the "sensitive oesophagus".

Authors:  R G Watson; T C Tham; B T Johnston; N I McDougall
Journal:  Gut       Date:  1997-05       Impact factor: 23.059

Review 2.  Nonerosive reflux disease--current concepts and dilemmas.

Authors:  R Fass; M B Fennerty; N Vakil
Journal:  Am J Gastroenterol       Date:  2001-02       Impact factor: 10.864

Review 3.  Psychophysiological interactions in esophageal diseases.

Authors:  J E Richter; L C Bradley
Journal:  Semin Gastrointest Dis       Date:  1996-10

4.  The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring.

Authors:  G J Wiener; J E Richter; J B Copper; W C Wu; D O Castell
Journal:  Am J Gastroenterol       Date:  1988-04       Impact factor: 10.864

5.  Sustained esophageal contraction: a motor correlate of heartburn symptom.

Authors:  N Pehlivanov; J Liu; R K Mittal
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2001-09       Impact factor: 4.052

6.  Diagnostic value of histology in non-erosive gastro-oesophageal reflux disease.

Authors:  N E Schindlbeck; B Wiebecke; A G Klauser; W A Voderholzer; S A Müller-Lissner
Journal:  Gut       Date:  1996-08       Impact factor: 23.059

7.  Duodenal fat intensifies the perception of heartburn.

Authors:  J H Meyer; A Lembo; J D Elashoff; R Fass; E A Mayer
Journal:  Gut       Date:  2001-11       Impact factor: 23.059

8.  Omeprazole as a diagnostic tool in gastroesophageal reflux disease.

Authors:  B E Schenk; E J Kuipers; E C Klinkenberg-Knol; H P Festen; E H Jansen; H A Tuynman; M Schrijver; L A Dieleman; S G Meuwissen
Journal:  Am J Gastroenterol       Date:  1997-11       Impact factor: 10.864

9.  The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors.

Authors:  L A Bradley; J E Richter; T J Pulliam; J M Haile; I C Scarinci; C A Schan; C B Dalton; A N Salley
Journal:  Am J Gastroenterol       Date:  1993-01       Impact factor: 10.864

10.  Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD.

Authors:  K C Trimble; A Pryde; R C Heading
Journal:  Gut       Date:  1995-07       Impact factor: 23.059
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  52 in total

Review 1.  Functional heartburn: definition and management strategies.

Authors:  Frank Zerbib; Stanislas Bruley des Varannes; Mireille Simon; Jean Paul Galmiche
Journal:  Curr Gastroenterol Rep       Date:  2012-06

2.  Determinants of perception of heartburn and regurgitation.

Authors:  A J Bredenoord; B L A M Weusten; W L Curvers; R Timmer; A J P M Smout
Journal:  Gut       Date:  2005-08-24       Impact factor: 23.059

3.  Erosions or not in GORD? The potential role of oesophageal cell proliferation.

Authors:  C Calabrese; G Cenacchi; D Trerè; A Fabbri; M Derenzini; M Miglioli; G Di Febo
Journal:  Gut       Date:  2005-06       Impact factor: 23.059

Review 4.  Treatment of uncomplicated reflux disease.

Authors:  Joachim Labenz; Peter Malfertheiner
Journal:  World J Gastroenterol       Date:  2005-07-28       Impact factor: 5.742

5.  A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country.

Authors:  Tiing-Leong Ang; Kwong-Ming Fock; Tay-Meng Ng; Eng-Kiong Teo; Tju-Siang Chua; Jessica Tan
Journal:  World J Gastroenterol       Date:  2005-06-21       Impact factor: 5.742

6.  Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces.

Authors:  Ricard Farré; Rita De Vos; Karel Geboes; Kristine Verbecke; Pieter Vanden Berghe; Inge Depoortere; Kathleen Blondeau; Jan Tack; Daniel Sifrim
Journal:  Gut       Date:  2007-02-01       Impact factor: 23.059

7.  Functional heartburn, nonerosive reflux disease, and reflux esophagitis are all distinct conditions--a debate: pro.

Authors:  Tomás Navarro-Rodriguez; Ronnie Fass
Journal:  Curr Treat Options Gastroenterol       Date:  2007-08

8.  [Antireflux therapy--more than acid reduction?].

Authors:  T Frieling
Journal:  Internist (Berl)       Date:  2004-12       Impact factor: 0.743

Review 9.  Current perspectives on the diagnosis and treatment of functional esophageal disorders.

Authors:  Roy Dekel; Ronnie Fass
Journal:  Curr Gastroenterol Rep       Date:  2003-08

Review 10.  NERD: an umbrella term including heterogeneous subpopulations.

Authors:  Edoardo Savarino; Patrizia Zentilin; Vincenzo Savarino
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-03-26       Impact factor: 46.802
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