| Literature DB >> 12423069 |
Francesco Gasparrini1, Domenico Misiti, Marco Pierini, Claudio Villani.
Abstract
We describe a novel macrocyclic minireceptor that is assembled from a chiral 1,2-diamine and 5-allyloxyisophthalic acid. After immobilization on HPLC silica, the chiral macrocycle preferentially binds the L-enantiomers of simple amino acid derivatives, with enantioselectivities values up to 3.0 kcal/mol. [structure: see text]Entities:
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Year: 2002 PMID： 12423069 DOI： 10.1021/ol026363g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005