Literature DB >> 12419546

5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus.

Jason J Radley1, Barry L Jacobs.   

Abstract

This study investigated the action of 5-HT(1A) receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant approximately 30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

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Year:  2002        PMID： 12419546     DOI： 10.1016/s0006-8993(02)03477-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  59 in total

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