Literature DB >> 12419367

Natural PTP1B inhibitors from Broussonetia papyrifera.

Rong Min Chen1, Li Hong Hu, Tian Ying An, Jia Li, Qiang Shen.   

Abstract

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.

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Year:  2002        PMID： 12419367     DOI： 10.1016/s0960-894x(02)00757-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

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4.  Chemical composition and antioxidant activities of Broussonetia papyrifera fruits.

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5.  Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes.

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8.  Microbial Transformation of Prenylquercetins by Mucor hiemalis.

Authors:  Fubo Han; Yina Xiao; Ik-Soo Lee
Journal:  Molecules       Date:  2020-01-25       Impact factor: 4.411

9.  Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure-Activity Relationship.

Authors:  Prangya Rath; Anuj Ranjan; Arabinda Ghosh; Abhishek Chauhan; Manisha Gurnani; Hardeep Singh Tuli; Hamza Habeeballah; Mustfa F Alkhanani; Shafiul Haque; Kuldeep Dhama; Naval Kumar Verma; Tanu Jindal
Journal:  Molecules       Date:  2022-03-29       Impact factor: 4.411

10.  Diverse Molecular Targets for Chalcones with Varied Bioactivities.

Authors:  Bo Zhou; Chengguo Xing
Journal:  Med Chem (Los Angeles)       Date:  2015-08-22
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