| Literature DB >> 12419362 |
Takeshi Shimizu1, Takeo Usui, Kiyotaka Machida, Kouichi Furuya, Hiroyuki Osada, Tadashi Nakata.
Abstract
Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.Entities:
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Year: 2002 PMID： 12419362 DOI： 10.1016/s0960-894x(02)00782-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823