| Literature DB >> 12417424 |
Abstract
Mucin-type O-glycans containing Core2 branches have distinctly different functions from those O-glycans that contain Core1 structures. Core2 branched O-glycans can have terminal structures that function as ligands for carbohydrate binding proteins. However, sialylated Core2 branched O-glycans without additional modifications exhibit anti-adhesive properties. These results demonstrate that certain mucin-type O-glycans can either facilitate or attenuate cell adhesion depending on the core structures and the structures of the non-reducing termini.Entities:
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Year: 2002 PMID： 12417424 DOI： 10.1016/s0304-4165(02)00409-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002