PURPOSE: Troglitazone, a potent activator of the peroxisome proliferator-activated receptor-gamma, induces tumor differentiation in human liposarcomas and causes regression of tumors that are derived from human colon cancer cells in nude mice. We therefore assessed the efficacy of troglitazone in the treatment of metastatic colon cancer in humans. METHODS: Twenty-five patients with metastatic colorectal cancer were treated with oral troglitazone. Patients were followed up for evidence of toxicity, tumor response, and survival. RESULTS: The treatment was well tolerated: no grade 3/4 treatment-related toxicities were observed. However, no objective tumor responses were noted, and all 25 patients had progressive disease as their best response to therapy. The median progression-free survival time was only 1.6 months, and the median survival time was 3.9 months. DISCUSSION: Troglitazone is not an active agent for the treatment of metastatic colorectal cancer.
PURPOSE:Troglitazone, a potent activator of the peroxisome proliferator-activated receptor-gamma, induces tumor differentiation in humanliposarcomas and causes regression of tumors that are derived from humancolon cancer cells in nude mice. We therefore assessed the efficacy of troglitazone in the treatment of metastatic colon cancer in humans. METHODS: Twenty-five patients with metastatic colorectal cancer were treated with oral troglitazone. Patients were followed up for evidence of toxicity, tumor response, and survival. RESULTS: The treatment was well tolerated: no grade 3/4 treatment-related toxicities were observed. However, no objective tumor responses were noted, and all 25 patients had progressive disease as their best response to therapy. The median progression-free survival time was only 1.6 months, and the median survival time was 3.9 months. DISCUSSION: Troglitazone is not an active agent for the treatment of metastatic colorectal cancer.
Authors: Patrick J Roberts; Jerry E Usary; David B Darr; Patrick M Dillon; Adam D Pfefferle; Martin C Whittle; James S Duncan; Soren M Johnson; Austin J Combest; Jian Jin; William C Zamboni; Gary L Johnson; Charles M Perou; Norman E Sharpless Journal: Clin Cancer Res Date: 2012-08-07 Impact factor: 12.531
Authors: P J Simpson-Haidaris; S J Pollock; S Ramon; N Guo; C F Woeller; S E Feldon; R P Phipps Journal: PPAR Res Date: 2010-02-28 Impact factor: 4.964
Authors: Geoffrey D Girnun; Elnaz Naseri; Scott B Vafai; Lishu Qu; Jeffrey D Szwaya; Roderick Bronson; John A Alberta; Bruce M Spiegelman Journal: Cancer Cell Date: 2007-05 Impact factor: 31.743
Authors: I Cellai; G Petrangolini; M Tortoreto; G Pratesi; P Luciani; C Deledda; S Benvenuti; C Ricordati; S Gelmini; E Ceni; A Galli; M Balzi; P Faraoni; M Serio; A Peri Journal: Br J Cancer Date: 2010-01-12 Impact factor: 7.640