Literature DB >> 12415311

Opinion: Interpretation of the complexity of innate immune responses by functional genomics.

Paola Ricciardi-Castagnoli1, Francesca Granucci.   

Abstract

Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.

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Year:  2002        PMID： 12415311     DOI： 10.1038/nri936

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  21 in total

Review 1.  Immunogenomics and systems biology of vaccines.

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Journal:  Immunol Rev       Date:  2011-01       Impact factor: 12.988

2.  Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection.

Authors:  Thomas Ruby; Catherine Whittaker; David R Withers; Mounira K Chelbi-Alix; Veronique Morin; Anne Oudin; John R Young; Rima Zoorob
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

3.  Expression of CD56 antigen in Langerhans cell histiocytosis associated with T-lymphoblastic lymphoma in a same lymph node.

Authors:  Young-Hyeh Ko; Won-Seog Kim; Yoonjung Kim
Journal:  Virchows Arch       Date:  2005-10-14       Impact factor: 4.064

Review 4.  Intestinal microbiota-related effects on graft-versus-host disease.

Authors:  Yusuke Shono; Melissa D Docampo; Jonathan U Peled; Suelen M Perobelli; Robert R Jenq
Journal:  Int J Hematol       Date:  2015-03-27       Impact factor: 2.490

5.  Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.

Authors:  Bradley A Carlson; Min-Hyuk Yoo; Marcus Conrad; Vadim N Gladyshev; Dolph L Hatfield; Jin Mo Park
Journal:  Mol Immunol       Date:  2011-09-22       Impact factor: 4.407

Review 6.  Lymphocytes in obesity-related adipose tissue inflammation.

Authors:  A Chatzigeorgiou; K P Karalis; S R Bornstein; T Chavakis
Journal:  Diabetologia       Date:  2012-06-26       Impact factor: 10.122

7.  Similarity of gene expression patterns in human alveolar macrophages in response to Pseudomonas aeruginosa and Burkholderia cepacia.

Authors:  Stefan Worgall; Adriana Heguy; Karsta Luettich; Timothy P O'Connor; Ben-Gary Harvey; Luis E N Quadri; Ronald G Crystal
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

8.  Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19.

Authors:  Daniela Giordano; Dario M Magaletti; Edward A Clark
Journal:  Blood       Date:  2005-10-25       Impact factor: 22.113

Review 9.  Systems vaccinology: its promise and challenge for HIV vaccine development.

Authors:  Helder I Nakaya; Bali Pulendran
Journal:  Curr Opin HIV AIDS       Date:  2012-01       Impact factor: 4.283

10.  Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.

Authors:  W L William Chang; Nicole Baumgarth; Dong Yu; Peter A Barry
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103
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