Literature DB >> 12409545

Controlling tuberculosis in India.

G R Khatri1, Thomas R Frieden.   

Abstract

BACKGROUND: Tuberculosis kills nearly 500,000 people in India each year. Until recently, less than half of patients with tuberculosis received an accurate diagnosis, and less than half of those received effective treatment.
METHODS: We analyzed the effects of new policies introduced in 1993 that have resulted in increased resources, improved laboratory-based diagnosis, direct observation of treatment, and the use of standardized antituberculosis regimens and reporting methods.
RESULTS: By September 2001, more than 200,000 health workers had been trained, and 436 million people (more than 40 percent of the entire population) had access to services. About 3.4 million patients had been evaluated for tuberculosis, and nearly 800,000 had received treatment, with a success rate greater than 80 percent. More than half of all those treated in the past 8 years were treated in the past 12 months.
CONCLUSIONS: India's tuberculosis-control program has been successful in improving access to care, the quality of diagnosis, and the likelihood of successful treatment. We estimate that the improved program has prevented 200,000 deaths, with indirect savings of more than $400 million--more than eight times the cost of implementation. It will be a substantial challenge to sustain and expand the program, given the country's level of economic development, limited primary health care system, and large and mostly unregulated private health care system, as well as the dual threats of the human immunodeficiency virus and multidrug-resistant tuberculosis. Copyright 2002 Massachusetts Medical Society

Entities:  

Mesh:

Year:  2002        PMID: 12409545     DOI: 10.1056/NEJMsa020098

Source DB:  PubMed          Journal:  N Engl J Med        ISSN: 0028-4793            Impact factor:   91.245


  35 in total

Review 1.  Tuberculosis in neonates and infants: epidemiology, pathogenesis, clinical manifestations, diagnosis, and management issues.

Authors:  Chrysanthi L Skevaki; Dimitrios A Kafetzis
Journal:  Paediatr Drugs       Date:  2005       Impact factor: 3.022

2.  The private health sector in India.

Authors:  Amit Sengupta; Samiran Nundy
Journal:  BMJ       Date:  2005-11-19

3.  The persistence of tuberculosis in the age of DOTS: reassessing the effect of case detection.

Authors:  David W Dowdy; Richard E Chaisson
Journal:  Bull World Health Organ       Date:  2009-04       Impact factor: 9.408

4.  Prevalence and risk factors for transmission of infection among children in household contact with adults having pulmonary tuberculosis.

Authors:  M Singh; M L Mynak; L Kumar; J L Mathew; S K Jindal
Journal:  Arch Dis Child       Date:  2005-06       Impact factor: 3.791

5.  A rare case of perforation peritonitis with jejunal stricture in a patient recently treated for pulmonary tuberculosis.

Authors:  Naveen N; Avijeet Mukherjee
Journal:  J Clin Diagn Res       Date:  2014-12-05

6.  Why do tuberculosis suspects bypass local services to attend tuberculosis sanatorium?

Authors:  Rajeswari Ramachandran; M Muniyandi; P G Gopi; Fraser Wares
Journal:  Lung India       Date:  2010-07

7.  Trends in tuberculosis incidence and their determinants in 134 countries.

Authors:  C Dye; K Lönnroth; E Jaramillo; B G Williams; M Raviglione
Journal:  Bull World Health Organ       Date:  2009-09       Impact factor: 9.408

8.  Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness.

Authors:  Ted Cohen; Megan Murray
Journal:  Nat Med       Date:  2004-09-19       Impact factor: 53.440

9.  Rapid and specific detection of Mycobacterium tuberculosis by using the Smart Cycler instrument and a specific fluorogenic probe.

Authors:  Timothy J Cleary; Gladys Roudel; Ofelia Casillas; Nancimae Miller
Journal:  J Clin Microbiol       Date:  2003-10       Impact factor: 5.948

10.  Phenylalanine-rich peptides potently bind ESAT6, a virulence determinant of Mycobacterium tuberculosis, and concurrently affect the pathogen's growth.

Authors:  Krishan Kumar; Megha Tharad; Swetha Ganapathy; Geeta Ram; Azeet Narayan; Jameel Ahmad Khan; Rana Pratap; Anamika Ghosh; Sachin Kumar Samuchiwal; Sushil Kumar; Kuhulika Bhalla; Deepti Gupta; Krishnamurthy Natarajan; Yogendra Singh; Anand Ranganathan
Journal:  PLoS One       Date:  2009-11-10       Impact factor: 3.240

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