Literature DB >> 12407441

MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.

Jason A Koutcher1, Xiaoyi Hu, Su Xu, Terence P F Gade, Norman Leeds, Xiaohong Joe Zhou, David Zagzag, Eric C Holland.   

Abstract

Magnetic resonance imaging (MRI) has been utilized for screening and detecting brain tumors in mice based upon their imaging characteristics appearance and their pattern of enhancement. Imaging of these tumors reveals many similarities to those observed in humans with identical pathology. Specifically, high-grade murine gliomas have histologic characteristics of glioblastoma multiforme (GBM) with contrast enhancement after intravenous administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), implying disruption of the blood-brain barrier in these tumors. In contrast, low-grade murine oligodendrogliomas do not reveal contrast enhancement, similar to human tumors. MRI can be used to identify mice with brain neoplasms as inclusion criteria in preclinical trials.

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Year:  2002        PMID： 12407441      PMCID： PMC1503661          DOI： 10.1038/sj.neo.7900269

Source DB:  PubMed          Journal:  Neoplasia        ISSN： 1476-5586            Impact factor:   5.715


  31 in total

Review 1.  Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation.

Authors:  P Vajkoczy; A Ullrich; M D Menger
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 2.  Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.

Authors:  J G Fujimoto; C Pitris; S A Boppart; M E Brezinski
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 3.  Use of reporter genes for optical measurements of neoplastic disease in vivo.

Authors:  C H Contag; D Jenkins; P R Contag; R S Negrin
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 4.  High resolution X-ray computed tomography: an emerging tool for small animal cancer research.

Authors:  M J Paulus; S S Gleason; S J Kennel; P R Hunsicker; D K Johnson
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 5.  Characterizing tumors using metabolic imaging: PET imaging of cellular proliferation and steroid receptors.

Authors:  D A Mankoff; F Dehdashti; A F Shields
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 6.  Fluorescence spectroscopy of neoplastic and non-neoplastic tissues.

Authors:  N Ramanujam
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

7.  Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy.

Authors:  L D Stegman; A Rehemtulla; D A Hamstra; D J Rice; S J Jonas; K L Stout; T L Chenevert; B D Ross
Journal:  Gene Ther       Date:  2000-06       Impact factor: 5.250

8.  Gliomas in rodent whisker barrel cortex: a new tumor model.

Authors:  E W Sherburn; J E Wanebo; P Kim; S K Song; M R Chicoine; T A Woolsey
Journal:  J Neurosurg       Date:  1999-11       Impact factor: 5.115

9.  A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

Authors:  E C Holland; W P Hively; R A DePinho; H E Varmus
Journal:  Genes Dev       Date:  1998-12-01       Impact factor: 11.361

10.  Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade.

Authors:  H C Roberts; T P Roberts; R C Brasch; W P Dillon
Journal:  AJNR Am J Neuroradiol       Date:  2000-05       Impact factor: 4.966
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  19 in total

1.  mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.

Authors:  Xiaoyi Hu; Pier Paolo Pandolfi; Yi Li; Jason A Koutcher; Marc Rosenblum; Eric C Holland
Journal:  Neoplasia       Date:  2005-04       Impact factor: 5.715

2.  Multiple-mouse MRI with multiple arrays of receive coils.

Authors:  Marc S Ramirez; Emilio Esparza-Coss; James A Bankson
Journal:  Magn Reson Med       Date:  2010-03       Impact factor: 4.668

3.  Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.

Authors:  C J Herting; Z Chen; K L Pitter; F Szulzewsky; I Kaffes; M Kaluzova; J C Park; P J Cimino; C Brennan; B Wang; D Hambardzumyan
Journal:  Glia       Date:  2017-08-24       Impact factor: 7.452

Review 4.  MR imaging features of high-grade gliomas in murine models: how they compare with human disease, reflect tumor biology, and play a role in preclinical trials.

Authors:  A R Borges; P Lopez-Larrubia; J B Marques; S G Cerdan
Journal:  AJNR Am J Neuroradiol       Date:  2011-12-22       Impact factor: 3.825

Review 5.  Imaging in neurooncology.

Authors:  Andreas H Jacobs; Lutz W Kracht; Axel Gossmann; Maria A Rüger; Anne V Thomas; Alexander Thiel; Karl Herholz
Journal:  NeuroRx       Date:  2005-04

Review 6.  Pathology and molecular genetics of astrocytic gliomas.

Authors:  Guido Reifenberger; Vincent Peter Collins
Journal:  J Mol Med (Berl)       Date:  2004-10       Impact factor: 4.599

7.  Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma.

Authors:  Ruimin Huang; Jelena Vider; Joy L Kovar; D Michael Olive; Ingo K Mellinghoff; Philipp Mayer-Kuckuk; Moritz F Kircher; Ronald G Blasberg
Journal:  Clin Cancer Res       Date:  2012-08-22       Impact factor: 12.531

8.  VEGF immunopositivity related to malignancy degree, proliferative activity and angiogenesis in ENU-induced gliomas.

Authors:  S Bulnes; J V Lafuente
Journal:  J Mol Neurosci       Date:  2007       Impact factor: 3.444

9.  Corticosteroids compromise survival in glioblastoma.

Authors:  Kenneth L Pitter; Ilaria Tamagno; Kristina Alikhanyan; Amira Hosni-Ahmed; Siobhan S Pattwell; Shannon Donnola; Charles Dai; Tatsuya Ozawa; Maria Chang; Timothy A Chan; Kathryn Beal; Andrew J Bishop; Christopher A Barker; Terreia S Jones; Bettina Hentschel; Thierry Gorlia; Uwe Schlegel; Roger Stupp; Michael Weller; Eric C Holland; Dolores Hambardzumyan
Journal:  Brain       Date:  2016-03-28       Impact factor: 13.501

10.  High-resolution longitudinal screening with magnetic resonance imaging in a murine brain cancer model.

Authors:  Nicholas A Bock; Gelareh Zadeh; Lori M Davidson; Baoping Qian; John G Sled; Abhijit Guha; R Mark Henkelman
Journal:  Neoplasia       Date:  2003 Nov-Dec       Impact factor: 5.715
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