Literature DB >> 12406628

Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine.

K Hamacher1, H H Coenen.   

Abstract

A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12406628     DOI： 10.1016/s0969-8043(02)00225-7

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  51 in total

1.  The use of dynamic O-(2-18F-fluoroethyl)-l-tyrosine PET in the diagnosis of patients with progressive and recurrent glioma.

Authors:  Norbert Galldiks; Gabriele Stoffels; Christian Filss; Marion Rapp; Tobias Blau; Caroline Tscherpel; Garry Ceccon; Veronika Dunkl; Martin Weinzierl; Michael Stoffel; Michael Sabel; Gereon R Fink; Nadim J Shah; Karl-Josef Langen
Journal:  Neuro Oncol       Date:  2015-05-24       Impact factor: 12.300

2.  Dual-time-point O-(2-[(18)F]fluoroethyl)-L-tyrosine PET for grading of cerebral gliomas.

Authors:  Philipp Lohmann; Hans Herzog; Elena Rota Kops; Gabriele Stoffels; Natalie Judov; Christian Filss; Norbert Galldiks; Lutz Tellmann; Carolin Weiss; Michael Sabel; Heinz Hubert Coenen; Nadim Jon Shah; Karl-Josef Langen
Journal:  Eur Radiol       Date:  2015-03-27       Impact factor: 5.315

3.  Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-L-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake.

Authors:  Carina Stegmayr; Gabriele Stoffels; Elena Rota Kops; Philipp Lohmann; Norbert Galldiks; Nadim J Shah; Bernd Neumaier; Karl-Josef Langen
Journal:  Mol Imaging Biol       Date:  2019-02       Impact factor: 3.488

4.  Spatial Relationship of Glioma Volume Derived from 18F-FET PET and Volumetric MR Spectroscopy Imaging: A Hybrid PET/MRI Study.

Authors:  Jörg Mauler; Andrew A Maudsley; Karl-Josef Langen; Omid Nikoubashman; Gabriele Stoffels; Sulaiman Sheriff; Philipp Lohmann; Christian Filss; Norbert Galldiks; Elena Rota Kops; N Jon Shah
Journal:  J Nucl Med       Date:  2017-08-28       Impact factor: 10.057

5.  Dynamic O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography differentiates brain metastasis recurrence from radiation injury after radiotherapy.

Authors:  Garry Ceccon; Philipp Lohmann; Gabriele Stoffels; Natalie Judov; Christian P Filss; Marion Rapp; Elena Bauer; Christina Hamisch; Maximilian I Ruge; Martin Kocher; Klaus Kuchelmeister; Bernd Sellhaus; Michael Sabel; Gereon R Fink; Nadim J Shah; Karl-Josef Langen; Norbert Galldiks
Journal:  Neuro Oncol       Date:  2017-02-01       Impact factor: 12.300

6.  Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-L-tyrosine PET in comparison to MRI.

Authors:  Norbert Galldiks; Marion Rapp; Gabriele Stoffels; Gereon R Fink; Nadim J Shah; Heinz H Coenen; Michael Sabel; Karl-Josef Langen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2012-09-29       Impact factor: 9.236

7.  Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas. Results of a prospective phase II study.

Authors:  M D Piroth; M Pinkawa; R Holy; J Klotz; S Schaar; G Stoffels; N Galldiks; H H Coenen; H J Kaiser; K J Langen; M J Eble
Journal:  Strahlenther Onkol       Date:  2012-02-22       Impact factor: 3.621

8.  Radiation injury vs. recurrent brain metastasis: combining textural feature radiomics analysis and standard parameters may increase 18F-FET PET accuracy without dynamic scans.

Authors:  Philipp Lohmann; Gabriele Stoffels; Garry Ceccon; Marion Rapp; Michael Sabel; Christian P Filss; Marcel A Kamp; Carina Stegmayr; Bernd Neumaier; Nadim J Shah; Karl-Josef Langen; Norbert Galldiks
Journal:  Eur Radiol       Date:  2016-11-16       Impact factor: 5.315

9.  O-(2-[18F]fluorethyl)-L-tyrosine PET in the clinical evaluation of primary brain tumours.

Authors:  M Weckesser; K J Langen; C H Rickert; S Kloska; R Straeter; K Hamacher; G Kurlemann; H Wassmann; H H Coenen; O Schober
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-01-14       Impact factor: 9.236

10.  Influence of blood-brain barrier permeability on O-(2-18F-fluoroethyl)-L-tyrosine uptake in rat gliomas.

Authors:  Carina Stegmayr; Ulrike Bandelow; Dennis Oliveira; Philipp Lohmann; Antje Willuweit; Christian Filss; Norbert Galldiks; Joachim H R Lübke; N Jon Shah; Johannes Ermert; Karl-Josef Langen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-09-09       Impact factor: 9.236
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.