Literature DB >> 12404636

A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration.

Kevin T Mc Henry1, Sudha V Ankala, Arun K Ghosh, Gabriel Fenteany.   

Abstract

We have developed a high-throughput assay for screening chemical libraries for compounds that affect cell sheet migration during wound closure in epithelial cell monolayers. By using this assay, we have discovered a new inhibitor of cell sheet migration. This compound (UIC-1005) is a 3,4-disubstituted oxazolidinone that bears an electrophilic alpha,beta-unsaturated N-acyl group required for activity. UIC-1005 also inhibits growth in an epithelial cell proliferation assay. The molecule does not display general toxicity at concentrations at which it potently inhibits cell sheet migration and growth. Unlike certain 3,5-disubstituted oxazolidinones, it exhibits no antibacterial activity. UIC-1005 therefore represents a new class of bioactive oxazolidinone derivative that may prove useful as a probe for signaling pathways leading to cell motility.

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Year:  2002        PMID： 12404636     DOI： 10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO;2-S

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  17 in total

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