Design and Synthesis of a Peptide That Binds Specific DNA Sequences through Simultaneous Interaction in the Major and in the Minor Groove This work was supported by the Spanish M.E.C. (PB97-0524) and the Xunta de Galicia (PGIDT00PXI20912PR). M.E.V. and A.M.C. thank the Xunta de Galicia and the University of Santiago for their predoctoral fellowships. We are very grateful to Prof. G. L. Verdine for his input and support in the early phases of this work. We also thank Prof. J. Benavente for allowing us to use the radioactivity facilities and Prof. C. Abell for critical reading of the manuscript.