| Literature DB >> 12399166 |
Alexandre Marin1, Hao Sun, Ghaleb A Husseini, William G Pitt, Douglas A Christensen, Natalya Y Rapoport.
Abstract
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20-100 kHz). Even a short (15-30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed.Entities:
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Year: 2002 PMID： 12399166 DOI： 10.1016/s0168-3659(02)00262-6
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776