| Literature DB >> 32601526 |
Prit Lakhani1,2, Akash Patil1,2, Pranjal Taskar1,2, Eman Ashour1,2, Soumyajit Majumdar1,2.
Abstract
The current study sought to formulate, optimize, and evaluate curcumin-loaded Nanostructured Lipid Carriers (NLCs) for their in vitro and ex vivo characteristics. NLCs, prepared using hot-melt emulsification and ultrasonication techniques, were optimized using a Central Composite Design (CCD) and evaluated for their in vitro physicochemical characteristics. Their stability over a 3 month period and transcorneal permeation across excised rabbit corneas (ex vivo) were assessed for the optimized NLCs. The optimized NLC, with a particle size of 66.8 ± 2 nm, polydispersity index of 0.17±0.05, entrapment efficiency of 96 ± 1.6%, and drug loading of 3.1 ± 0.05% w/w, was chosen using CCD. The optimized NLCs showed optimum ex vivo stability at 4°C for the study period and demonstrated a significant increase in curcumin permeation (~2.5-fold) across the rabbit cornea in comparison to the control. Overall, these studies indicated the successful development of NLCs using the design of experiment approach; the formulation enhanced curcumin permeation across excised corneas and did not show any harmful side effects.Entities:
Year: 2018 PMID： 32601526 PMCID： PMC7324022 DOI： 10.1016/j.jddst.2018.07.010
Source DB: PubMed Journal: J Drug Deliv Sci Technol ISSN： 1773-2247 Impact factor: 3.981