Literature DB >> 12398889

Telomerase: a target for cancer therapeutics.

Jerry W Shay1, Woodring E Wright.   

Abstract

The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

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Year:  2002        PMID： 12398889     DOI： 10.1016/s1535-6108(02)00159-9

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  64 in total

Review 1.  Molecular biology of breast cancer.

Authors:  Miguel Martín
Journal:  Clin Transl Oncol       Date:  2006-01       Impact factor: 3.405

2.  Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.

Authors:  Christina Y Soohoo; Rong Shi; Tae Ho Lee; Pengyu Huang; Kun Ping Lu; Xiao Zhen Zhou
Journal:  J Biol Chem       Date:  2010-11-30       Impact factor: 5.157

Review 3.  The biogenesis and regulation of telomerase holoenzymes.

Authors:  Kathleen Collins
Journal:  Nat Rev Mol Cell Biol       Date:  2006-07       Impact factor: 94.444

4.  Genes and pathways downstream of telomerase in melanoma metastasis.

Authors:  Sepideh Bagheri; Mehdi Nosrati; Shang Li; Sylvia Fong; Sima Torabian; Javier Rangel; Dan H Moore; Scot Federman; Rebecca R Laposa; Frederick L Baehner; Richard W Sagebiel; James E Cleaver; Christopher Haqq; Robert J Debs; Elizabeth H Blackburn; Mohammed Kashani-Sabet
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-17       Impact factor: 11.205

5.  PathScan: a tool for discerning mutational significance in groups of putative cancer genes.

Authors:  Michael C Wendl; John W Wallis; Ling Lin; Cyriac Kandoth; Elaine R Mardis; Richard K Wilson; Li Ding
Journal:  Bioinformatics       Date:  2011-04-14       Impact factor: 6.937

6.  HPV E6 protein interacts physically and functionally with the cellular telomerase complex.

Authors:  Xuefeng Liu; Aleksandra Dakic; Yiyu Zhang; Yuhai Dai; Renxiang Chen; Richard Schlegel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-20       Impact factor: 11.205

Review 7.  Prospects and challenges of building a cancer vaccine targeting telomerase.

Authors:  Robert H Vonderheide
Journal:  Biochimie       Date:  2007-07-17       Impact factor: 4.079

8.  Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.

Authors:  Rebecca L Tomlinson; Eladio B Abreu; Tania Ziegler; Hinh Ly; Christopher M Counter; Rebecca M Terns; Michael P Terns
Journal:  Mol Biol Cell       Date:  2008-06-18       Impact factor: 4.138

9.  Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells.

Authors:  Masahiro Kato; Masahiro Nakayama; Minako Agata; Kenichi Yoshida
Journal:  Tumour Biol       Date:  2012-12-18

10.  Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek's disease virus (MDV).

Authors:  Najat Chbab; Annemarie Egerer; Inês Veiga; Keith W Jarosinski; Nikolaus Osterrieder
Journal:  Vet Res       Date:  2010-04-29       Impact factor: 3.683
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