Literature DB >> 12397471

Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction.

Hiroshi Matsuda1, Hidekazu Kanetaka, Takashi Ohnishi, Takashi Asada, Etsuko Imabayashi, Seigo Nakano, Asako Katoh, Fumiko Tanaka.   

Abstract

The aim of this study was to determine which brain structures show the greatest influence of partial volume effects (PVE) in single-photon emission tomography (SPET) studies on Alzheimer's disease (AD). Brain perfusion SPET was performed in 30 patients with probable AD and 62 age-matched healthy volunteers. SPET images were corrected for PVE using grey matter volume segmented from magnetic resonance images. The most prominent changes after PVE correction were observed in the medial temporal structures. The PVE correction revealed a selective decrease in regional cerebral blood flow (rCBF) in the parahippocampal gyrus of AD without rCBF decreases in the hippocampus, which had been observed before correction. This correction seems to be essential in order to achieve accurate measurements of rCBF in SPET, which has limited spatial resolution.

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Year:  2002        PMID： 12397471     DOI： 10.1007/s00259-002-0930-2

Source DB:  PubMed          Journal:  Eur J Nucl Med Mol Imaging        ISSN： 1619-7070            Impact factor:   9.236


  17 in total

Review 1.  Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?

Authors:  Tyler A Kokjohn; Chera L Maarouf; Alex E Roher
Journal:  Alzheimers Dement       Date:  2011-11-02       Impact factor: 21.566

2.  Comparison of gray matter and metabolic reduction in mild Alzheimer's disease using FDG-PET and voxel-based morphometric MR studies.

Authors:  Kazunari Ishii; Hiroki Sasaki; Atsushi K Kono; Naokazu Miyamoto; Tetsuya Fukuda; Etsuro Mori
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-03-31       Impact factor: 9.236

3.  Whither the hippocampus? FDG-PET hippocampal hypometabolism in Alzheimer disease revisited.

Authors:  J A Maldjian; C T Whitlow
Journal:  AJNR Am J Neuroradiol       Date:  2012-06-14       Impact factor: 3.825

4.  Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience.

Authors:  Nathan A Johnson; Geon-Ho Jahng; Michael W Weiner; Bruce L Miller; Helena C Chui; William J Jagust; Maria L Gorno-Tempini; Norbert Schuff
Journal:  Radiology       Date:  2005-03       Impact factor: 11.105

5.  Age-associated reductions in cerebral blood flow are independent from regional atrophy.

Authors:  J Jean Chen; H Diana Rosas; David H Salat
Journal:  Neuroimage       Date:  2010-12-16       Impact factor: 6.556

6.  Brain FDG PET study of normal aging in Japanese: effect of atrophy correction.

Authors:  Daisuke Yanase; Ichiro Matsunari; Kazuyoshi Yajima; Weiping Chen; Akihiko Fujikawa; Shintaro Nishimura; Hiroshi Matsuda; Masahito Yamada
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-03-10       Impact factor: 9.236

7.  Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data.

Authors:  Douglas N Greve; Claus Svarer; Patrick M Fisher; Ling Feng; Adam E Hansen; William Baare; Bruce Rosen; Bruce Fischl; Gitte M Knudsen
Journal:  Neuroimage       Date:  2013-12-19       Impact factor: 6.556

8.  Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging.

Authors:  Norbert Schuff; Shinji Matsumoto; Joseph Kmiecik; Colin Studholme; Antao Du; Frank Ezekiel; Bruce L Miller; Joel H Kramer; William J Jagust; Helen C Chui; Michael W Weiner
Journal:  Alzheimers Dement       Date:  2009-11       Impact factor: 21.566

9.  Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT.

Authors:  Hidekazu Kanetaka; Hiroshi Matsuda; Takashi Asada; Takashi Ohnishi; Fumio Yamashita; Etsuko Imabayashi; Fumiko Tanaka; Seigo Nakano; Masaru Takasaki
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-02-28       Impact factor: 9.236

10.  Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults.

Authors:  Swati Rane; Brandon A Ally; Erin Hussey; Tracy Wilson; Tricia Thornton-Wells; John C Gore; Manus J Donahue
Journal:  Hippocampus       Date:  2012-10-26       Impact factor: 3.899
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