Literature DB >> 12397177

Potentiation of serum response factor activity by a family of myocardin-related transcription factors.

Da-Zhi Wang1, Shijie Li, Dirk Hockemeyer, Lillian Sutherland, Zhigao Wang, Gerhard Schratt, James A Richardson, Alfred Nordheim, Eric N Olson.   

Abstract

Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.

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Year:  2002        PMID： 12397177      PMCID： PMC137508          DOI： 10.1073/pnas.222561499

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

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Authors:  S Sachdev; L Bruhn; H Sieber; A Pichler; F Melchior; R Grosschedl
Journal:  Genes Dev       Date:  2001-12-01       Impact factor: 11.361

2.  Muscle specificity encoded by specific serum response factor-binding sites.

Authors:  P S Chang; L Li; J McAnally; E N Olson
Journal:  J Biol Chem       Date:  2001-02-05       Impact factor: 5.157

3.  Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.

Authors:  Y Hiroi; S Kudoh; K Monzen; Y Ikeda; Y Yazaki; R Nagai; I Komuro
Journal:  Nat Genet       Date:  2001-07       Impact factor: 38.330

4.  Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

Authors:  Z Ma; S W Morris; V Valentine; M Li; J A Herbrick; X Cui; D Bouman; Y Li; P K Mehta; D Nizetic; Y Kaneko; G C Chan; L C Chan; J Squire; S W Scherer; J K Hitzler
Journal:  Nat Genet       Date:  2001-07       Impact factor: 38.330

5.  Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.

Authors:  D Wang; P S Chang; Z Wang; L Sutherland; J A Richardson; E Small; P A Krieg; E N Olson
Journal:  Cell       Date:  2001-06-29       Impact factor: 41.582

6.  elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.

Authors:  V N Rao; K Huebner; M Isobe; A ar-Rushdi; C M Croce; E S Reddy
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Authors:  Chong Hyun Shin; Zhi-Ping Liu; Robert Passier; Chun-Li Zhang; Da-Zhi Wang; Thomas M Harris; Hiroyuki Yamagishi; James A Richardson; Geoffrey Childs; Eric N Olson
Journal:  Cell       Date:  2002-09-20       Impact factor: 41.582

8.  Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation.

Authors:  B Weinhold; G Schratt; S Arsenian; J Berger; K Kamino; H Schwarz; U Rüther; A Nordheim
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

9.  Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells.

Authors:  G Schratt; B Weinhold; A S Lundberg; S Schuck; J Berger; H Schwarz; R A Weinberg; U Rüther; A Nordheim
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

10.  Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.

Authors:  C Norman; M Runswick; R Pollock; R Treisman
Journal:  Cell       Date:  1988-12-23       Impact factor: 41.582
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  198 in total

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Authors:  Mayssa H Mokalled; Aaron Johnson; Yuri Kim; Jiyeon Oh; Eric N Olson
Journal:  Development       Date:  2010-06-09       Impact factor: 6.868

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Authors:  Samir Ounzain; Satoru Kobayashi; Richard E Peterson; Aibin He; Anna Motterle; Nilesh J Samani; Donald R Menick; William T Pu; Qiangrong Liang; Nelson W Chong
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Journal:  J Biol Chem       Date:  2015-11-10       Impact factor: 5.157

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Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

5.  HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy.

Authors:  Yasuo Hamamori; Michael D Schneider
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

6.  Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.

Authors:  Ellyn R Montgomery; Brenda R S Temple; Kimberly A Peters; Caitlin E Tolbert; Brandon K Booker; Joseph W Martin; Tyler P Hamilton; Alicia C Tagliatela; William C Smolski; Stephen L Rogers; Alan M Jones; Thomas E Meigs
Journal:  Mol Pharmacol       Date:  2014-01-16       Impact factor: 4.436

7.  HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo.

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8.  Myocardin is sufficient for a smooth muscle-like contractile phenotype.

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Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-05-01       Impact factor: 8.311

9.  Signalling molecules involved in mouse bladder smooth muscle cellular differentiation.

Authors:  Benchun Liu; Dongxiao Feng; Guiting Lin; Mei Cao; Yuet Wai Kan; Gerald R Cunha; Laurence S Baskin
Journal:  Int J Dev Biol       Date:  2010       Impact factor: 2.203

10.  Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

Authors:  Taisuke Sawada; Chiharu Nishiyama; Takuma Kishi; Tomonari Sasazuki; Sachiko Komazawa-Sakon; Xin Xue; Jiang-Hu Piao; Hideko Ogata; Jun-ichi Nakayama; Tomohiko Taki; Yasuhide Hayashi; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157
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