| Literature DB >> 11431691 |
Z Ma1, S W Morris, V Valentine, M Li, J A Herbrick, X Cui, D Bouman, Y Li, P K Mehta, D Nizetic, Y Kaneko, G C Chan, L C Chan, J Squire, S W Scherer, J K Hitzler.
Abstract
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.Entities:
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Year: 2001 PMID： 11431691 DOI： 10.1038/90054
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330