Literature DB >> 12396318

The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos.

J-P Guthmann1, S Kasparian, R Phetsouvanh, N Nathan, M Garcia, S Phompida, A Brockman, M Gastellu, D Legros.   

Abstract

To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.

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Year:  2002        PMID： 12396318     DOI： 10.1179/000349802125001654

Source DB:  PubMed          Journal:  Ann Trop Med Parasitol        ISSN： 0003-4983


  8 in total

1.  In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.

Authors:  Kasia Stepniewska; Walter R J Taylor; Mayfong Mayxay; Ric Price; Frank Smithuis; Jean-Paul Guthmann; Karen Barnes; Hla Yin Myint; Martin Adjuik; Piero Olliaro; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Tran Tinh Hien; Jeremy Farrar; François Nosten; Nicholas P J Day; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

2.  Selection strength and hitchhiking around two anti-malarial resistance genes.

Authors:  Denae Nash; Shalini Nair; Mayfong Mayxay; Paul N Newton; Jean-Paul Guthmann; François Nosten; Tim J C Anderson
Journal:  Proc Biol Sci       Date:  2005-06-07       Impact factor: 5.349

3.  In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

Authors:  Mayfong Mayxay; Marion Barends; Alan Brockman; Anchalee Jaidee; Shalini Nair; Dan Sudimack; Tiengkham Pongvongsa; Samlane Phompida; Rattanaxay Phetsouvanh; Tim Anderson; Nicholas J White; Paul N Newton
Journal:  Am J Trop Med Hyg       Date:  2007-02       Impact factor: 2.345

4.  Monitoring Plasmodium falciparum chloroquine resistance in Yunnan Province, China, 1981-2006.

Authors:  Henglin Yang; Yaming Yang; Pinfang Yang; Xingliang Li; Baihe Gao; Zhiyong Zhang; Zhaoqing Yang; Liwang Cui
Journal:  Acta Trop       Date:  2008-09-06       Impact factor: 3.112

5.  Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos.

Authors:  Mayfong Mayxay; Maniphone Khanthavong; Odai Chanthongthip; Mallika Imwong; Tiengkham Pongvongsa; Bouasy Hongvanthong; Samalane Phompida; Viengxay Vanisaveth; Nicholas J White; Paul N Newton
Journal:  Malar J       Date:  2012-06-08       Impact factor: 2.979

6.  An assessment of early diagnosis and treatment of malaria by village health volunteers in the Lao PDR.

Authors:  Viengvaly Phommanivong; Khanti Thongkham; Gopinath Deyer; Jean P Rene; Hubert Barennes
Journal:  Malar J       Date:  2010-12-01       Impact factor: 2.979

7.  Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data.

Authors: 
Journal:  BMC Med       Date:  2022-03-07       Impact factor: 8.775

8.  Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières.

Authors:  Jean-Paul Guthmann; Francesco Checchi; Ingrid van den Broek; Suna Balkan; Michel van Herp; Eric Comte; Oscar Bernal; Jean-Marie Kindermans; Sarah Venis; Dominique Legros; Philippe J Guerin
Journal:  PLoS Med       Date:  2008-08-05       Impact factor: 11.069
  8 in total

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