OBJECTIVE: To evaluate the fetal survival rate using a modified technique to surgically create a 'myelomeningocele-like' defect in a rabbit model. METHODS: Six white New Zealand rabbits had a spinal defect created in their fetuses at 23 days of gestation. At 30 days of gestation, the fetuses were harvested for anatomo-pathologic evaluation. RESULTS: The defect was created in 19 fetuses and an attempt to correct it was made in 15 cases (group I), and 4 fetuses where left without correction (group II). At 30 days, a 'myelomeningocele-like' defect was present in all surviving fetuses. The total survival rate was 73.68% (14/19); 11 fetus survived in group I and 3 in group II. CONCLUSION: The technical modifications, including fetal positioning and exposure of its back prior to the incision of the lamina, associated with a different technique for myometrium closure, offer an alternative and probably safer method to surgically create a spinal defect in the fetal rabbit. Copyright 2002 S. Karger AG, Basel
OBJECTIVE: To evaluate the fetal survival rate using a modified technique to surgically create a 'myelomeningocele-like' defect in a rabbit model. METHODS: Six white New Zealand rabbits had a spinal defect created in their fetuses at 23 days of gestation. At 30 days of gestation, the fetuses were harvested for anatomo-pathologic evaluation. RESULTS: The defect was created in 19 fetuses and an attempt to correct it was made in 15 cases (group I), and 4 fetuses where left without correction (group II). At 30 days, a 'myelomeningocele-like' defect was present in all surviving fetuses. The total survival rate was 73.68% (14/19); 11 fetus survived in group I and 3 in group II. CONCLUSION: The technical modifications, including fetal positioning and exposure of its back prior to the incision of the lamina, associated with a different technique for myometrium closure, offer an alternative and probably safer method to surgically create a spinal defect in the fetal rabbit. Copyright 2002 S. Karger AG, Basel
Authors: César G Fontecha; Jose L Peiró; Marius Aguirre; Francesc Soldado; Patricia Paz; Marc Oria; Núria Torán; Vicenç Martinez-Ibáñez Journal: Pediatr Surg Int Date: 2007-05 Impact factor: 1.827
Authors: Luc Joyeux; Alexander C Engels; Johannes Van Der Merwe; Michael Aertsen; Premal A Patel; Marjolijn Deprez; Ahmad Khatoun; Savitree Pranpanus; Marina Gabriela Monteiro Carvalho Mori da Cunha; Stephanie De Vleeschauwer; Johanna Parra; Katerina Apelt; Myles Mc Laughlin; Frank Van Calenbergh; Enrico Radaelli; Jan Deprest Journal: Sci Rep Date: 2019-06-27 Impact factor: 4.379